What tests are conducted for nephrotic syndrome?

Written by Zhang Hui

Nephrology

Updated on September 25, 2024

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Patients with nephrotic syndrome need to complete routine urine tests, 24-hour urine protein quantification, liver and kidney function tests, routine blood tests, electrolyte panels, blood glucose tests, and lipid profiles. Additionally, it is important to determine the cause of nephrotic syndrome, excluding the possibility of nephrotic syndrome caused by immune system diseases, including tumors, vasculitis, lupus, and other diseases. These tests include rheumatoid immune panels, antinuclear antibody spectrum, anti-GBM antibodies, ANCA panel, and immunoglobulins. Moreover, these patients should undergo kidney ultrasound, tumor marker tests, and thyroid function tests.

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Written by Li Liu Sheng

Nephrology

1min 10sec

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Conditions for discontinuing medication for nephrotic syndrome

The main clinical manifestations of nephrotic syndrome are significant proteinuria and hypoproteinemia, along with varying degrees of hyperlipidemia and edema. Nephrotic syndrome often requires treatment with corticosteroids. The general principle for using steroids is to start with a sufficient dosage and administer it slowly, maintaining it for a long duration, approximately around one year. Therefore, the conditions for discontinuing medication in nephrotic syndrome include: if the patient has been treated with steroids for about a year, and the proteinuria has resolved, 24-hour urinary protein quantification is normal, there is no edema, blood albumin levels have returned to normal, and kidney function is also normal, then discontinuation of steroid treatment can be considered. Of course, after stopping the medication, it is essential to regularly visit the hospital for monitoring of routine urine tests, kidney function, and blood pressure to prevent the recurrence of nephrotic syndrome due to infections or fatigue.

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Written by Zhou Qi

Nephrology

46sec

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What to do if nephrotic syndrome causes leg pain?

Patients with nephrotic syndrome who experience leg pain mostly have conditions unrelated to nephrotic syndrome itself. It could be due to diseases of the skeletal or muscular system. However, some patients might experience leg pain due to thrombosis caused by nephrotic syndrome, leading to ischemia in the limbs. Also, long-term use of corticosteroids can lead to necrosis of the femoral head, osteoporosis, and pain. Therefore, treatment should be targeted based on the cause, such as using drugs to dissolve clots or interventional surgery for those with thrombosis. In severe cases of femoral head necrosis, a femoral head replacement surgery might be necessary, and it is important to supplement with calcium regularly.

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Written by Niu Yan Lin

Nephrology

42sec

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Does nephrotic syndrome require a puncture?

Nephrotic syndrome is a complex of clinical symptoms with various causes, which differ by age group. In children or adolescents, if it presents solely as significant proteinuria without elevated creatinine or hematuria, it is generally caused by minimal change disease. Since this type of kidney disease is sensitive to hormone treatment, it is usually possible to forego renal biopsy and start with corticosteroid therapy. For other nephrotic syndrome patients, it is advisable to first perform a renal biopsy to identify the pathological cause before considering appropriate treatment with hormones, immunosuppressants, and other medications.

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Written by Zhou Qi

Nephrology

45sec

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Why does nephrotic syndrome cause sleepiness?

Excessive sleepiness is not a common clinical manifestation of nephrotic syndrome; generally, patients with nephrotic syndrome rarely exhibit excessive sleepiness. If a patient does display sleepiness, it is necessary to investigate the causes, such as a reduction in blood volume and decreased blood pressure caused by nephrotic syndrome, leading to insufficient cerebral blood supply. Furthermore, in cases of nephrotic syndrome, the patient’s immune capacity decreases, making them more susceptible to various infections, such as infections of the upper respiratory tract and lungs. When inflamed, patients are also likely to feel excessively sleepy. In some patients, there is a risk of cerebral infarction, which can also cause sleepiness.

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Written by Wu Ji

Nephrology

48sec

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Criteria for the diagnosis of nephrotic syndrome

The diagnostic criteria for nephrotic syndrome include massive proteinuria, with urinary protein greater than 3.5 grams/day, hypoalbuminemia, with plasma albumin less than 30 grams/liter, severe edema, and hyperlipidemia, which includes significant increases in plasma cholesterol and triglycerides. The first two criteria are essential for the diagnosis of nephrotic syndrome, while the latter two are secondary. Clinically, if the two necessary criteria are met, the diagnosis of nephrotic syndrome is established. Patients with nephrotic syndrome should undergo a renal biopsy to determine the pathological type and guide clinical treatment.