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Yan Xin Liang
Pediatrics
About me
Graduated from Nanhua University, engaged in pediatric work for over 10 years, and have further studied at Hunan Children's Hospital, Xiangya Hospital, and Beijing Children's Hospital.
Proficient in diseases
Diagnosis and treatment of common diseases in pediatric internal medicine, especially skilled in the diagnosis and treatment of pediatric respiratory system and neurological diseases, such as pediatric convulsions, epilepsy, asthma, and lung infections...
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The earliest manifestation of phenylketonuria
Children with phenylketonuria usually start showing symptoms within 3 to 6 months after birth: Firstly, the nervous system is affected, which can be seen in developmental delays in intelligence, often with IQs lower than normal. Symptoms may include restlessness, depression, hyperactivity, or minor epileptic seizures. A few may exhibit increased muscle tone or heightened tendon reflexes. A few months after birth, due to insufficient melanin synthesis, the skin and hair undergo changes. Hair color may shift from black to yellow, the skin may appear very pale, and eczema is also more common. Additionally, because of the excretion of greater amounts of phenylacetic acids in urine and sweat, there may be a distinct mouse-like urine odor.
Do children with myocarditis have a fever?
In general, viral myocarditis is the most common form of myocarditis in children. This condition can be caused by various viruses such as influenza, parainfluenza, Coxsackie virus, adenovirus, etc., affecting the pediatric cardiac muscle tissue, which in turn can lead to symptoms of myocarditis. Since it is an infectious disease, fever is a common symptom. Fevers associated with myocarditis might present as high or moderate. Treatment primarily focuses on cardiac recovery, nourishing the cardiac muscle, steroids, and immunoglobulins, among others. Severe myocarditis is a critical condition that requires timely diagnosis and treatment to avoid worsening the situation.
What to do if the baby has thrush?
Oral thrush is caused by the parasitic proliferation of Candida albicans in the mucous membrane of the mouth. It is a secondary infection typically seen in individuals with weakened immune systems or those who have been using antibiotics for an extended period. In such cases, initially, one can use a 2.5% sodium bicarbonate solution to rinse the mouth, specifically targeting the areas affected by thrush. After meals, crush nystatin tablets and apply the powder to the areas with thrush, using this method three times a day. Additionally, taking probiotics orally, such as Bifidobacteria, can aid in treatment. Generally, these measures can control the condition within 3 to 5 days.
Tetralogy of Fallot shadow on the radiograph
Tetralogy of Fallot is the most common cyanotic heart disease in children over the age of one, accounting for about 10 percent of all congenital heart diseases. Tetralogy of Fallot includes four anatomical abnormalities: a ventricular septal defect, right ventricular outflow tract obstruction, an overriding aorta, and right ventricular hypertrophy. In patients diagnosed through X-ray, the heart size is often within normal limits, typically appearing boot-shaped, with markedly reduced pulmonary vascular markings. The aortic arch may be located on the right side, and the ascending aorta is usually dilated. Patients with rich collateral circulation display prominent pulmonary markings.
How to treat enteritis in children
How to treat enteritis in children? First, it is necessary to assess whether the enteritis is caused by a virus or a bacterial infection. If it is simply viral enteritis, the first step generally involves rehydration, which can be provided through oral rehydration salts to replenish fluids and electrolytes. Additionally, probiotics such as Bifidobacterium or Lactobacillus acidophilus can be given to regulate the intestinal flora, and smectite can be used to protect the gastrointestinal mucosa. If it is viral diarrhea, antiviral medications can also be added to the treatment. If the diarrhea is considered to be caused by a bacterial infection in the intestines, some antibiotics can be administered orally, including cephalosporins or penicillin antibiotics. If the infection is severe, intravenous therapy may be necessary.
What are the symptoms of epilepsy in children?
The typical symptoms of childhood epilepsy include sudden loss of consciousness, followed initially by tonic and then clonic convulsions, often accompanied by screaming, cyanotic facial complexion, frothing or bleeding at the mouth, dilated pupils, generally lasting 40 seconds or up to 15 minutes. The convulsive seizure stops naturally, followed by a state of coma. Of course, some affected children also display varying degrees of consciousness disorders, evident disruptions in thinking, perception, emotion, and psychomotor functions, and may show signs of conditions like somnambulism and noctambulism, among other automatisms.
Causes of Phenylketonuria
The cause of phenylketonuria is that phenylalanine is an essential amino acid for the human body. Some of the phenylalanine ingested is used for protein synthesis, while another part is converted into tyrosine by the action of phenylalanine hydroxylase. Only a small amount of phenylalanine undergoes a secondary metabolic pathway and is converted into phenylpyruvate under the action of transaminase. Due to the reduced activity of phenylalanine hydroxylase in affected children, phenylalanine cannot be converted into tyrosine, leading to an extremely high concentration of phenylalanine in blood, cerebrospinal fluid, and tissues. This, through a bypass metabolic pathway, results in the production of a large amount of phenylpyruvate, phenylacetate, phenyllactate, and p-hydroxyphenylacetate. The high concentration of phenylalanine and its metabolic products then leads to brain damage, which is the cause of the disease.
Is the incidence of phenylketonuria high?
Phenylketonuria is an autosomal recessive hereditary disease and is the most common congenital amino acid metabolic disorder. The main clinical manifestations include distinctive features such as intellectual disability, light skin and hair pigmentation, and a mouse-like urine odor, which is named after the large amounts of phenylketone acid metabolites excreted in the urine. The incidence of this disease varies by race and region, and the overall incidence in China is approximately 1:11,000, meaning one in eleven thousand. The incidence is higher in the northern population than in the southern population, though it is not particularly high.
How is hand, foot, and mouth disease transmitted?
Hand, foot, and mouth disease is an infectious disease caused by enteroviral infections. There are more than 20 types of enteroviruses that can cause hand, foot, and mouth disease, but the most common are Coxsackievirus A16 and Enterovirus 71. The main clinical symptoms include pain in the mouth, anorexia, low fever, and the appearance of small vesicles or ulcers on the hands, feet, mouth, and other areas. Most children can recover in about a week, but a few may develop serious complications such as myocarditis, pulmonary edema, and aseptic meningitis. The general transmission routes are through the digestive tract, respiratory tract, and close contact, such as through droplets, sharing utensils, and hand-to-mouth contact, etc.
Newborn pneumonia symptoms
If a newborn gets pneumonia, it can manifest as coughing, although some newborns may not cough at all, showing only symptoms like spitting white foam. Some may have a mild fever, while others may experience slightly rapid breathing. More severe cases can present with cyanosis of the lips, unhealthy-looking facial complexion, or a bluish purple facial color. These are signs of severe pneumonia. Additionally, there might be a decrease in urine output, poor responsiveness, etc. The symptoms of pneumonia in newborns are relatively less typical than those in older infants and toddlers.