Does thyroid nodule puncture hurt?

Written by Hu Jian Zhuo
Nephrology and Endocrinology
Updated on September 29, 2024
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Fine needle aspiration is an invasive examination, but it is currently an important and most efficient method for assessing benign and malignant conditions, generally conducted under ultrasound guidance. Thyroid nodule aspiration does not cause much pain, similar to that of an injection. Anesthetics are used during the procedure, so the pain is not very noticeable. However, as the effect of the anesthetic wears off, there may still be some pain at the puncture site, but the patients do not need to carry a heavy psychological burden.

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Written by Zhang Jun Jun
Endocrinology
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How to cure thyroid nodules

The treatment of thyroid nodules is primarily based on whether the nodules are benign or malignant. For nodules that are highly suspected to be malignant clinically, or are confirmed to be suspiciously malignant or malignant through thyroid fine needle aspiration, surgical treatment is required and generally yields good results. The second type is benign nodules, for which studies have shown that treatment with levothyroxine can suppress and reduce the size of the nodules, but this is only effective in some iodine-deficient areas. Another type is hyperfunctioning hot nodules, which can be treated with isotope therapy and radioactive iodine. Additionally, if the thyroid nodule causes compressive symptoms, appears behind the sternum or within the mediastinum, and is associated with high-risk factors for thyroid cancer, surgical removal is recommended. For benign thyroid nodules, usually, only regular follow-up with thyroid ultrasound is required; if the ultrasound follow-up shows more than a 50% increase in the size of the thyroid nodule, further thyroid fine needle aspiration is needed, and surgery may be necessary if required.

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Written by Hu Jian Zhuo
Nephrology and Endocrinology
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Are thyroid nodules serious?

The severity of thyroid nodules needs to be assessed based on their nature, size, function, and location. Generally, they can be classified into benign and malignant, with malignant nodules being thyroid cancer, which requires timely treatment. Surgical treatment is the main method for treating thyroid cancer, whereas most benign nodules do not require special handling. Regarding the size of the thyroid nodules, if the nodules are too large and compress surrounding tissues such as the trachea, esophagus, and nerves, surgical treatment is recommended. For common benign nodules, regular observation is sufficient. Functionally, some thyroid nodules may affect thyroid function, such as in Hashimoto's thyroiditis, which can present with diffuse multiple nodules, leading to either hyperthyroidism or hypothyroidism. In such cases, appropriate medication treatment is needed. From a positional perspective, ectopic growth of thyroid nodules, if located at areas like the base of the ear, pharynx, neck, esophagus, or thoracic cavity, is a rare congenital developmental anomaly. If such a nodule significantly enlarges and compresses surrounding tissues, surgical treatment is advised.

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Nephrology and Endocrinology
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Symptoms of thyroid nodules

Thyroid nodules in the early stages often show no clear symptoms, with only small nodules appearing within the body. The size of these nodules can range from several millimeters to several centimeters, and their texture is generally slightly harder compared to the surrounding glandular tissue. When the enlargement is more noticeable, the nodule can move up and down with the thyroid gland during swallowing. In addition to the presence of nodules, when the thyroid nodule is prominent, it can compress the trachea, leading to difficulty breathing and irritative dry cough. If it compresses the recurrent laryngeal nerve, it may cause hoarseness, varying degrees of hoarseness, and even an inability to speak loudly. In patients with malignant nodules, the invasive malignant cells can cause symptoms such as hoarseness, difficulty breathing, dysphagia (difficulty swallowing), diarrhea, palpitations, facial flushing, and decreased blood calcium levels. If these symptoms occur, it is crucial to seek medical attention promptly.

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Differentiation between benign and malignant thyroid nodules

Generally speaking, whether benign or malignant, thyroid nodules show blood flow signals. For benign nodules, blood flow signals can be seen around the perimeter, with internal blood flow no different from normal thyroid tissue. In such cases, the nodules are typically diagnosed as thyroid adenomas, and they usually appear round or oval in shape with a uniformly echoic internal substance. If liquefaction occurs, mixed or cystic changes can appear; the tumor’s capsule tends to be intact, with clear boundaries. If a nodule has abundant internal blood flow with disorganized vessel distribution and high flow velocity, showing a high-resistance flow pattern, and has relatively less peripheral blood flow, it generally needs to be assessed for thyroid cancer. These nodules are often hypoechoic with irregular shapes, and the ratio of their longitudinal to transverse diameter is greater than 1. They have unclear boundaries, lack a capsule, and have no halo. In typical cases, microcalcifications like sand grains can also be observed. From the above analysis, we can see that the blood flow signals in thyroid nodules are complicated and reflect the extent of the nodular pathology. These signals can help in differentiating benign from malignant nodules, but when a rich and disorganized blood flow is observed, the nodule is more likely to be malignant.

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Written by Hu Jian Zhuo
Nephrology and Endocrinology
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How to treat thyroid nodules?

Clinically, if a thyroid nodule is confirmed to be a benign tumor, generally speaking, if thyroid function is normal and the nodule is not large, urgent treatment is not necessary, and regular follow-up is sufficient. If the thyroid nodule significantly enlarges, causing compression of the trachea or nerves, surgery should be considered. Furthermore, for ectopic growth of thyroid tissue behind the sternum, surgical removal is also considered necessary. Another scenario that requires special mention is if a thyroid nodule grows rapidly in a short period and ultrasound suggests calcification or bleeding within the cyst, thyroid cancer should be suspected. In this case, it's advisable to have the nodule surgically removed.