Angular cheilitis generally exhibits a phenomenon of being long-lasting and difficult to cure, which may be related to inflammatory irritation. When the inflammation is not fully resolved, the infection associated with angular cheilitis may not easily subside.

It is important for angular cheilitis to be treated actively with anti-infection methods and symptomatic treatments. During dry seasons, which are peak periods for triggering angular cheilitis, it is advisable for patients to avoid licking their lips when they feel dry. Doing so can actually increase the moisture on the lips, leading to the skin at the corners of the mouth being more susceptible to breakdown and secondary infection from surrounding diseases. For example, Candida albicans, a common type of fungus, can frequently infect these areas. Not only can this cause angular cheilitis, but it can also lead to recurrent episodes. Patients are advised to pay attention to their lifestyle habits.