Patients with cheilitis will not see therapeutic effects from taking metronidazole. There are many causes of cheilitis in clinical practice. Once diagnosed with cheilitis, patients should first eliminate any irritating factors, such as frequent licking or biting of the lips, which should be corrected. In dry or cold weather, extra attention should be paid to applying lip balm or doing local moist compresses to keep the lips hydrated. If cheilitis is caused by exposure to sunlight or other similar reasons, patients should focus on sun protection to avoid prolonged sun exposure. In such cases, since there is no bacterial infection, taking metronidazole will not be effective in treatment.