For dry and flaky cheilitis, it is often diagnosed clinically as exfoliative cheilitis, commonly occurring in young women, potentially related to cosmetics and other factors. It is necessary to enhance lip moisturizing care and avoid using decorative cosmetics. Consistent use of medical lip balm is recommended, as well as avoiding licking the lips and consuming spicy and irritating foods. Eating more fruits and vegetables rich in vitamins is advisable. Oral medications such as levocetirizine tablets, total paeony glycoside capsules, and hydroxychloroquine sulfate tablets should be taken to provide anti-allergic, anti-inflammatory, and immunomodulating symptomatic treatment. Topical applications like pimecrolimus cream or compound heparin sodium cream can be used on affected lip areas. Early in the treatment based on the condition, short-term use of corticosteroids, such as desonide cream, may be employed to control symptoms. (Note: Medication should be used under the guidance of a physician)