Cheilitis is common in clinical settings and can be caused by various factors, including some that may be allergic in nature, requiring the intake of antiallergic medication as anti-inflammatory drugs are ineffective. Common antiallergic medications, such as loratadine, can provide significant anti-allergic effects. Topically, anti-allergic medications like dexamethasone acetate cream can also be applied to achieve a certain level of anti-allergic effect. For patients with contact cheilitis, it is recommended not to use antibiotics, as they generally do not have a significant effect on local lip inflammation. It is suggested that patients apply erythromycin ointment locally, which can also provide a good anti-inflammatory effect. The inflammation occurs at the epidermal extremities of the lips, and orally administered antibiotics, when they reach the lips, are usually at a low concentration and do not provide an effective anti-inflammatory effect. It is advised that patients primarily focus on local care, paying attention to the protection of the lip area and keeping it relatively moist. (Medication should be used under the guidance of a professional doctor.)