Neuroblastoma is divided into several types.

Written by Chen Yu Fei
Neurosurgery
Updated on June 11, 2025
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Neuroblastoma can be classified into several types, such as abdominal neuroblastoma, which often presents with obvious abdominal distention. Patients may experience difficulty defecating, dry stools, and stubborn constipation. Thoracic neuroblastoma mainly presents with obvious difficulty in breathing, accompanied by shortness of breath, frequent breathing, and low blood oxygen saturation. Spinal neuroblastoma primarily causes a noticeable decrease in trunk and limb strength, with most patients experiencing significant limb motor dysfunction and difficulty walking.

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Written by Chen Yu Fei
Neurosurgery
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Symptoms of neuroblastoma recurrence

For neuroblastoma, when the tumor recurs, the patient's original symptoms such as headaches, dizziness, nausea, and vomiting will reappear, occurring intermittently and worsening persistently. Most patients will experience significant increased intracranial pressure, and even frequent nausea and vomiting. Additionally, some neuroblastoma patients experience severe vertigo, especially when changing body positions, where the vertigo is particularly pronounced. For such patients, when the above symptoms and signs occur, they should go to a local hospital as soon as possible for a reassessment using cranial MRI to monitor changes in their condition.

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Written by Chen Yu Fei
Neurosurgery
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How to check for neuroblastoma?

For the examination of neuroblastoma, we generally recommend a neurological examination to help determine whether there are any clear positive signs, as well as to inquire about medical history and family history to judge if there are any cases of neuroblastoma among family members. Additionally, detailed laboratory tests, routine blood tests, routine urine tests, and biochemical tests, including tumor-related diagnostics, can help in making assessments. Of course, the most accurate and crucial examinations are CT or MRI scans of the head. If necessary, an enhanced MRI scan of the head can be conducted to further evaluate the location, nature, severity of the tumor, and its relationship with the surrounding neural and vascular tissues, which helps provide a basis for further surgical treatment.

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Written by Chen Yu Fei
Neurosurgery
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Age of onset of neuroblastoma

Neuroblastoma, typically arises from primitive neural crest cells, is more commonly found in the sympathetic ganglia and adrenal medulla. There is no specific age for the onset of neuroblastoma, but research indicates that it is more commonly diagnosed in children. The exact causative factors of neuroblastoma are not yet fully understood, but it is widely believed to involve congenital genetic factors, including acquired genetic mutations. Clinically, the presentation largely depends on the location of the tumor, the age at diagnosis, and the degree of malignancy of the tumor. In most cases, the tumor originates in the abdominal cavity, with a higher occurrence in the adrenal glands in children.

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Written by Kang Li
Neurosurgery
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Symptoms of Neuroblastoma

Typical symptoms of neuroblastoma include anemia and fatigue, excitement, no weight gain or weight loss, or irregular fever. The initial symptoms in the course of a short disease are not typical. Early diagnosis is difficult. Nonspecific symptoms include fatigue, loss of appetite, fever, joint pain. Those occurring within the skull display a bit of central nervous system cursing symptoms and symptoms of intracranial hypertension. Main manifestation. Occurrence outside the skull depends on the location of the tumor and the metastatic sites. Involvement of the thoracic cavity can cause chest and back pain and difficulty breathing, involvement of the abdominal cavity is characterized by abdominal distension, constipation, dysentery, and involvement of the spinal canal manifests as reduced strength in the trunk and limbs, and motor and sensory disturbances.

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Written by Gao Yi Shen
Neurosurgery
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Is calcification of neuroblastoma good?

In clinical practice, although calcification is a relatively favorable phenomenon, the overall condition of neuroblastoma does not change significantly because of it. Therefore, it is still not a good sign. For neuroblastoma, whether calcification occurs or not, it remains a form of tumor. Only through early surgical treatment can the problem be fundamentally resolved, otherwise, there is a tendency for recurrence and metastasis to occur later on. Moreover, it is important to note that regardless of whether the tumor calcifies, its nature does not change. Only fundamental treatment can bring better hope, so calcification does not lead to very good outcomes.