For patients with pituitary tumors, they often present with headaches, typically located behind the eye sockets, forehead, and both temporal areas. In the early stages of the disease, the nature of the headache is relatively mild and intermittent, mostly due to direct stimulation by the tumor or due to increased intrasellar pressure causing compression of the pituitary dural sac and the diaphragm sellae. When the tumor breaks through the diaphragm sellae, the intrasellar pressure gradually decreases, and the pain may gradually lessen or disappear. In the later stages of the disease, headaches may occur due to the tumor spreading to the parasellar region, invading the dura and vessels at the skull base, and compressing the trigeminal nerve, causing severe pain. In rare cases, due to a large pituitary adenoma growing upward into the third ventricle, breaking through and causing obstruction of the foramen of Monroe or the cerebral aqueduct, progressive intracranial pressure increases.