Osteoporosis can be painful, and the clinical manifestations of osteoporosis are threefold: first, pain; second, vertebral deformation; third, fragile fractures. Pain is the earliest symptom of osteoporosis, which can be localized pain, generalized pain, aching pain, or dull pain. Therefore, for older individuals or women around the time of menopause, if there is unexplained pain, and no primary or secondary lesions can be found, osteoporosis should be considered. In fact, the examination for osteoporosis is quite simple. Currently, the most commonly used clinical examinations are radiological and biochemical tests. In radiological tests, DXA, which stands for Dual-energy X-ray Absorptiometry, is the gold standard for clinical diagnosis. In addition, some bone markers can be tested, making diagnosis fairly straightforward. Therefore, osteoporosis can be painful, and if there is unexplained generalized pain in conjunction with age and gender, osteoporosis should be considered.