Osteoporosis is a systemic metabolic disease characterized by low bone mass and destruction of bone tissue microstructure, leading to increased bone fragility and susceptibility to fractures. Osteoporosis is common in the elderly but can occur at any age. Effective pharmacological treatments can prevent and treat osteoporosis, including estrogen replacement therapy, calcitonin, selective estrogen receptor modulators, and bisphosphonates, which can prevent bone resorption but have little effect on bone formation. Medications used to treat and prevent the development of osteoporosis fall into two main categories: the first category includes drugs that inhibit bone resorption, such as calcium supplements, vitamin D and active vitamin D, calcitonin, bisphosphonates, estrogen, and isoflavones; the second category includes drugs that promote bone formation, such as fluoride, synthetic steroids, and isoflavones. In addition to pharmacotherapy, patients should also enhance nutrition with a high-protein diet, calcium, and various vitamins. High protein is beneficial for the formation of bone matrix, and calcium supplementation can promote calcium balance. Milk, rich in protein and calcium, is an ideal treatment diet, and it is also advisable to take appropriate amounts of calcium tablets, vitamin D, and vitamin C.