Optic neuritis is a demyelinating disease caused by an inflammatory response, a disorder resulting from an immune dysfunction of the body. Thus, corticosteroids play a critical role in its treatment, and are widely used clinically. However, corticosteroids also have some side effects, such as causing osteoporosis, decalcification, and even necrosis of the femoral head, leading to significant obesity in patients due to redistribution of some fats, resulting in conditions like moon face and buffalo hump, and other adverse reactions including acne. Additionally, corticosteroids can have stimulating effects, potentially causing symptoms like insomnia and tachycardia; they also have gastrointestinal side effects, leading to acute ulcers and gastric mucosal lesions.