What are the causes of acute pancreatitis?

Written by Guo Li Ming
Gastroenterology
Updated on March 24, 2025
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There are many causes of acute pancreatitis. Common primary causes include improper diet: overeating, alcohol consumption, preference for spicy or rich foods, etc. Additionally, hyperlipidemia and cholelithiasis are also reasons, along with surgical trauma such as cholangiography, gastrectomy, etc. Other diseases can also lead to acute pancreatitis, such as hypercalcemia, diabetic coma, hyperparathyroidism, rheumatism, necrotizing vasculitis, etc.; viral infections can also cause pancreatitis, and long-term use of medications can cause acute inflammation, such as tetracycline, corticosteroids, etc. Acute pancreatitis initially presents with severe, acute abdominal pain, commonly in the left, upper middle quadrant, and occasionally radiating to the back. Subsequently, vomiting, fever, and in severe cases, shock may occur. Acute pancreatitis is a type of acute abdomen and can be life-threatening. If symptoms occur, it is crucial to seek immediate hospital treatment.

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Written by Wu Hai Wu
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Can you drink water with acute pancreatitis?

Patients with acute pancreatitis cannot drink water or eat anything during the acute phase. They must undergo gastrointestinal decompression to suction out gastric juice, gastric acid, and gastric contents. At the same time, treatment for acute pancreatitis includes inhibiting pancreatic secretion, anti-infection measures, intravenous fluid replenishment, and maintaining electrolyte balance, among others. If a patient with acute pancreatitis experiences bowel movements, gas, relief from abdominal pain, and a decrease in blood amylase to normal levels, they may then consider drinking small amounts of water and consuming light foods like rice soup or thin porridge. If the abdominal pain disappears, the patient can gradually increase their water intake.

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Written by Li Qiang
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How long does it take to cure acute severe pancreatitis?

Acute severe pancreatitis is a disease with a long treatment period and high treatment costs. Acute severe pancreatitis is pathologically staged, generally divided into the organ failure phase, also known as the inflammatory response phase. Typically, this occurs within 7 days after the onset of severe pancreatitis, during which there is a massive release of inflammatory factors, causing multiple organ failures. This stage is perilous and often requires the support of multiple organ functions, such as ventilators and hemofiltration treatments. After this inflammatory response phase, it transitions into a chronic phase of abdominal infection, which occurs approximately one week to one or two months after the onset. At this time, there is a large amount of effusion in the abdominal cavity, and some of the effusion may develop secondary infections. The main treatment at this stage involves puncture drainage of the effusion. Once an infection is detected, puncture drainage is performed on the infected site to manage the infection. Therefore, the treatment period for severe pancreatitis primarily depends on the duration of organ function support, recovery time of organ functions, and the severity of the infection. Some organ function support may be prolonged, requiring several months, and sometimes irreversible conditions occur, such as acute renal failure transitioning into chronic renal failure. Abdominal infections are more complex. If the infection is severe and recurrent, long-term puncture drainage or surgical removal of the infection may be necessary, often requiring several months of treatment.

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Written by Wei Shi Liang
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Is acute severe pancreatitis serious?

Acute severe pancreatitis is a very serious disease in clinical practice, with a high mortality rate, often requiring comprehensive treatment in the ICU. Acute severe pancreatitis is a disease caused by multiple etiologies that results in localized inflammation, necrosis, and infection of the pancreas, accompanied by a systemic inflammatory response and persistent organ failure. It is divided into three phases. The first phase is the acute response phase, occurring from onset to about two weeks, characterized by systemic inflammatory response; the second phase is the systemic infection phase, occurring from two weeks to about two months, characterized by necrosis and infection of the pancreas or peripancreatic tissues; the third phase is the residual infection phase, occurring two to three months later, with clinical manifestations primarily of systemic malnutrition and persistent fistulas, accompanied by gastrointestinal fistulas.

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Written by He Zong Quan
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Does acute pancreatitis have anything to do with the stomach?

Acute pancreatitis is not closely related to stomach conditions, although it is sometimes associated with overeating, but it is not caused by stomach diseases in patients. Instead, it relates to lifestyle habits. The occurrence of pancreatitis is often considered to be due to biliary, alcoholic, hyperlipidemia, and idiopathic causes. In China, the most common causes are biliary and alcohol-related. Biliary causes are mainly related to gallstones, while alcohol-related causes are mostly associated with drinking. Common stomach diseases include gastritis, ulcers, and stomach cancer. These conditions can sometimes cause an increase in amylase during acute abdominal conditions, but they do not cause acute pancreatitis.

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What to do about nausea and vomiting with acute pancreatitis?

Acute pancreatitis is also relatively common in clinical practice, and it is definitely a concern because there is a possibility that the condition may exacerbate. Therefore, as soon as acute pancreatitis is diagnosed, it is recommended to adopt fasting and hospitalization treatment regardless of whether there are symptoms of nausea or vomiting, providing gastrointestinal decompression and acid-suppressing inhibitors to prevent the progression of the condition. Mild acute pancreatitis can cause nausea and vomiting, but with targeted treatment and close observation, the symptoms can generally be quickly alleviated. Acute pancreatitis is often considered to be caused by biliary sources, alcohol, or hyperlipidemia, and different measures should be taken according to the specific cause.