Generally, patients with intrahepatic bile duct stones do not experience weight loss. If there is a significant weight decrease over a short period of time, resulting in weight loss or even cachexia, attention should be raised. It is necessary to complete relevant examinations to determine if there are malignant tumors. For patients with intrahepatic bile duct stones, although they may repeatedly experience upper abdominal pain and discomfort, along with nausea and vomiting, and sometimes concurrent cholangitis that results in jaundice, generally, it does not affect their weight. Of course, the condition of patients with intrahepatic bile duct stones should be actively managed. For treatment, typically, laparoscopic choledochotomy for stone removal is chosen, which can completely eliminate the stones and significantly improve the patients' quality of life.