Breast nodules are a symptom commonly associated with breast hyperplasia and neoplastic breast diseases. In treatment, it is crucial to first make an accurate diagnosis through breast ultrasound and mammography. If some nodules are highly likely to be benign, regular follow-up observation may be considered. If a biopsy is needed for some breast nodules to determine their pathological nature, the treatment plan can be decided based on the pathology results. If diagnosed as malignant tumors, a personalized comprehensive treatment plan should be developed in collaboration with multiple disciplines based on the patient's condition, including surgery, chemotherapy, radiotherapy, endocrine therapy, and molecular targeted therapy, among others.