Iron deficiency anemia clinical manifestations

Written by He Li Fang
Hematology
Updated on September 28, 2024
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Iron deficiency anemia presents in a variety of ways, including symptoms of anemia and iron deficiency. The main manifestation is tissue and organ hypoxia caused by iron deficiency, and severe iron deficiency anemia can lead to mucosal tissue changes and ectoderm nutritional disorders. Among the symptoms, we can find that in the early stages, the symptoms are relatively concealed and hard to detect. Patients with a slow progression can often adapt well in the early stages and are able to engage in daily work. Common symptoms of anemia include dizziness, headache, fatigue, and tiredness, along with palpitations and shortness of breath after activity, and even symptoms such as blurred vision and tinnitus. For patients with iron deficiency, specific symptoms include angular cheilitis, atrophy of the tongue papillae, glossitis, and severe iron deficiency patients may experience koilonychia, decreased appetite, nausea, and even constipation. Some patients, particularly children during their growth periods, may exhibit delayed growth and behavioral abnormalities, specifically being irritable and easily angered, having difficulty concentrating in class, and declining academic performance. A few patients may also develop pica, which is a special manifestation of iron deficiency anemia. In terms of physical signs, patients may exhibit pallor of the skin and mucous membranes, dry hair, and keratinization of the lips. Nails may be flat, lackluster, and prone to breakage, and a small number of patients may experience mild splenomegaly. These are the clinical manifestations of iron deficiency anemia.

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Written by He Li Fang
Hematology
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Why is there iron deficiency anemia?

Iron deficiency anemia refers to the anemia that occurs when the body's stored iron is depleted and can no longer meet the needs for normal red blood cell production. Before the production of red blood cells is limited, the body's iron stores are exhausted, but at this time, there are no obvious changes of anemia in the routine blood test; this condition is called iron deficiency. Iron deficiency anemia has its characteristics. Its main clinical manifestations are tissue and organ hypoxia caused by ischemia. Severe iron deficiency anemia can lead to mucosal tissue changes and some nutritional disorders, such as stomatitis, glossitis, atrophic gastritis, lack of gastric acid, dry skin, brittle hair, hair loss, and flat nails, among other changes. Therefore, any factors that cause iron deficiency in the body and affect iron absorption, including increased physiological iron demands, iron storage, and issues in iron excretion processes, can lead to iron deficiency anemia. The main causes can be divided into three aspects:1. Nutritional factors: Individuals such as infants, adolescents, menstruating women, pregnant women, and breastfeeding women are prone to nutritional iron deficiency anemia when the body's iron demand increases.2. Chronic blood loss: This includes gastrointestinal bleeding, heavy menstrual bleeding in women, bleeding hemorrhoids in men, and chronic bleeding from gastrointestinal ulcers, all of which can cause iron deficiency anemia.3. Absorption disorders: Conditions like total or partial gastrectomy can lead to iron deficiency years after the surgery, resulting in iron deficiency anemia.

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Written by He Li Fang
Hematology
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How long should iron supplements be taken for iron deficiency anemia?

First, it's important to understand that in treating iron deficiency anemia, addressing the underlying cause is the top priority. It's crucial to eliminate the causes of iron deficiency as much as possible. Solely supplementing with iron can only restore the blood picture, and neglecting the treatment of the primary illness will not lead to a thorough treatment of the anemia. Once the medication for anemia is stopped, it can easily relapse. So how long should iron supplements be taken for iron deficiency anemia? Generally, after patients start taking iron supplements, they can quickly feel an improvement in symptoms. The reticulocyte count tends to rise within three to four days after starting the supplements, reaching a peak around seven days. Hemoglobin shows a significant increase two weeks after starting the medication and can return to normal levels within one to two months. However, even after hemoglobin returns to normal, iron treatment should continue until the serum ferritin level has returned to 50 micrograms per liter before stopping the medication. If it's not possible to monitor serum ferritin, then iron supplements should be continued for three more months after hemoglobin has normalized, to replenish the body's iron stores. Therefore, the treatment of iron deficiency anemia with iron supplements generally lasts for three to six months.

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Written by He Li Fang
Hematology
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Iron deficiency anemia lacks what element?

Iron deficiency anemia refers to a type of anemia caused by a lack of stored iron in the body, which affects the synthesis of hemoglobin. Its characteristics include a lack of stainable iron in organs such as the bone marrow, liver, and spleen, leading to decreased serum iron concentration, decreased transferrin saturation, and decreased serum ferritin. Typical iron deficiency anemia presents as microcytic hypochromic anemia. Therefore, iron deficiency anemia involves a deficiency in iron, a trace element essential for the human body, which is widely present in cells and participates in the body's metabolic processes. The human body has a strict iron metabolism regulatory mechanism to maintain normal physiological levels. Once this homeostasis is disrupted, it can lead to the occurrence of iron deficiency anemia. Factors that affect the distribution, absorption, transport, and storage of iron can all cause iron deficiency anemia.

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Hematology
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Iron deficiency anemia should see which department?

Anemia is a condition characterized by a reduction in the total volume of red blood cells in the circulating blood to below normal levels. Iron deficiency anemia is a type of anemia caused by a lack of raw materials for blood production. Iron deficiency anemia occurs when the body's stored iron is depleted and cannot meet the needs for normal red blood cell production. Iron deficiency anemia is a common type of red blood cell disease and falls within the category of hematology. Therefore, patients with iron deficiency anemia should seek treatment in the department of hematology.

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Written by He Li Fang
Hematology
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How is iron deficiency anemia diagnosed?

The diagnosis of iron deficiency anemia includes two aspects: one is to establish whether there is anemia caused by iron deficiency, and the other is to clarify the cause of the iron deficiency. First, we need to carefully inquire and analyze the medical history, combined with the patient's physical examination, which can provide a series of clues for diagnosing iron deficiency anemia. A definitive diagnosis also requires laboratory evidence. Clinically, we can divide iron deficiency and iron deficiency anemia into three stages: iron deficiency, iron-deficient erythropoiesis, and iron deficiency anemia. The following describes the diagnostic criteria for iron deficiency anemia specifically. Iron deficiency anemia is characterized by a significant reduction in hemoglobin in red blood cells, presenting as microcytic hypochromic anemia. Its diagnostic basis includes three aspects: first, conforming to the diagnosis of iron deficiency and iron-deficient erythropoiesis; second, having microcytic hypochromic anemia; and third, effective treatment with iron supplements. These three factors together can confirm the diagnosis of this disease.