Causes of Endometrial Cancer

Written by Xu Xiao Ming
Obstetrics and Gynecology
Updated on March 30, 2025
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Patients with endometrial cancer generally have factors such as hypertension, diabetes, and obesity that induce the condition. They are more prone to developing endometrial cancer. Furthermore, endometrial cancer is divided into hormone-dependent and non-hormone-dependent types. Hormone-dependent endometrial cancer occurs when there is an excess of estrogen produced in the body without sufficient counteraction by progesterone, leading to excessive growth and proliferation of the endometrial lining. When this growth becomes uncontrolled, it can lead to cancer. Non-hormone-dependent endometrial cancer is not caused by hormonal factors and its development is more complex. Additionally, the pathology type of non-hormone-dependent endometrial cancer is also quite unique.

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Written by Tang Mei Xiang
Obstetrics and Gynecology
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How is endometrial cancer diagnosed?

Endometrial cancer often manifests as vaginal bleeding after menopause, and in women who have not experienced menopause, it often presents as menstrual irregularities. The diagnostic methods for endometrial cancer include the following: 1. Fractional curettage is the most important method for diagnosing endometrial cancer. First, scrape the cervical canal, then sequentially scrape the endometrial tissue from each part of the uterine body, label the specimens separately, and send them for pathological examination together. 2. Cytological examination is a method for screening for endometrial cancer. A specially made uterine cavity suction tube or brush is inserted into the uterine cavity to collect secretions for cytological culture. 3. Hysteroscopic examination allows direct observation of the growth of endometrial lesions and can also obtain live tissue for pathological examination. It involves pelvic ultrasound examination to understand the size of the lesion, surrounding infiltration, etc. 5. Other methods, such as lymphangiography, CT, MRI, and serum CA125 testing.

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Written by Li Lin
Obstetrics and Gynecology
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Are uterine cancer and endometrial cancer the same?

Uterine cancer is divided into cervical cancer and endometrial cancer. Cervical cancer is a malignant tumor that occurs in the epithelium and glandular tissue of the cervix, while endometrial cancer is a group of epithelial malignant tumors that occur in the endometrium. The two types of cancer differ due to their different sites of origin. Accordingly, the examination and treatment methods adopted are also not completely the same based on the different sites of origin. However, both cervical and endometrial cancers are primarily treated with surgery, followed by corresponding radiotherapy and chemotherapy.

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Written by Li Shun Hua
Obstetrics and Gynecology
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Is endometrial hyperplasia cancer?

Endometrial hyperplasia is not the same as endometrial cancer; it can be treated promptly. Endometrial cancer develops from ongoing endometrial hyperplasia, which can progress into atypical hyperplasia, a precancerous condition of the endometrium. Further development can lead to endometrial cancer. Therefore, it is crucial to treat endometrial hyperplasia actively to prevent its progression to endometrial cancer. Endometrial hyperplasia results from a lack of progesterone influence, causing the endometrium to remain in a proliferative state rather than transitioning to the secretory phase. With the influence of progesterone, the endometrium would not undergo hyperplasia; therefore, treating endometrial hyperplasia with progesterone is advisable.

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Written by Du Rui Xia
Obstetrics
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Can endometrial cancer patients become pregnant?

After the occurrence of endometrial cancer, it is not possible to become pregnant. This is because, after pregnancy, a woman's immunity decreases, and her resistance to illness declines. This will affect the woman's health and may exacerbate the condition of endometrial cancer. Additionally, women with endometrial cancer, even if they become pregnant, may experience miscarriages as the embryo cannot develop normally, and even many harmful symptoms might occur, affecting the woman's health. Therefore, women with endometrial cancer should take contraceptive measures to prevent unintended pregnancies.

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Written by Xu Xiao Ming
Obstetrics and Gynecology
47sec home-news-image

Does endometrial cancer require chemotherapy?

Whether chemotherapy is needed for endometrial cancer depends on its clinical stage. If it is advanced endometrial cancer, such as stage IV, chemotherapy is necessary for these patients. Recurrent endometrial cancer also requires chemotherapy. In the case of early-stage endometrial cancer, surgery can be used. The purpose of the surgery is to stage the pathology of the cancer to determine the extent of endometrial cancer infiltration. After the surgery, it will be assessed whether chemotherapy is needed. Therefore, whether chemotherapy is needed for endometrial cancer depends on the surgical staging. Some endometrial cancers may require not only chemotherapy but also radiotherapy treatment.