Amyotrophic lateral sclerosis (ALS) refers to a motor neuron disease. Patients with this disease generally do not experience numbness in the hands, mainly because it primarily affects the motor system and does not impact the sensory system. Thus, the vast majority of patients will not have sensory disturbances or experience clinical manifestations of numbness in the hands. The specific causes and mechanisms of this disease are still not very clear, but they may be related to genetic factors, the toxic effects of excitatory amino acids, oxidative stress, and mitochondrial dysfunction. Symptoms in patients gradually worsen, and respiratory function impairment may also occur. However, so far, there is no effective cure.