During a cold, one should not drink alcohol.

Patients with a cold often experience nasal congestion, runny nose, sneezing, and sore throat. Some may feel general body aches and weakness. Drinking alcohol can potentially worsen these clinical symptoms, especially since patients are prone to gastrointestinal disturbances during a cold, particularly those with a gastrointestinal type of cold who exhibit significant nausea, abdominal pain, and diarrhea. Continuing to drink alcohol can lead to a severe worsening of digestive symptoms, and even lead to watery diarrhea and symptoms of collapse.

Some patients with a cold may experience a fever induced by drinking alcohol, which can worsen and prolong the illness. Sometimes, drinking alcohol can lead to secondary bacterial infections of the respiratory tract, forming a bacterial type of cold and worsening the condition. Moreover, cold patients may need to take oral medication, and drinking alcohol could exacerbate the adverse reactions of these medications. Specifically, in cases of bacterial colds where cephalosporin anti-inflammatory drugs are required, drinking alcohol can cause a disulfiram-like reaction. Therefore, it is advisable to avoid alcohol during a cold.