Why do benign teratomas recur?

Written by Yan Chun
Oncology
Updated on December 10, 2024
00:00
00:00

Benign teratomas, although not aggressive or metastatic, do not require adjuvant chemotherapy or radiation therapy after curative surgery to fight the tumor. However, many benign teratomas recur after surgery and require further surgical treatment. The cause of benign teratoma recurrence is considered to be due to the persistent presence of oncogenic factors. Therefore, benign tumors can also recur, since the exact cause and pathogenesis of benign teratomas are still unclear clinically. Thus, prevention from an etiological perspective is not possible, and the only option is timely surgical removal upon tumor detection to prevent the benign teratoma from becoming malignant. For patients with benign teratomas, regular follow-up is necessary after curative surgery to monitor any changes in the condition. If signs of recurrence are detected, prompt intervention is necessary to prevent malignancy.

Other Voices

doctor image
home-news-image
Written by Liu Jian Wei
Obstetrics and Gynecology
34sec home-news-image

Can teratomas recur?

Teratomas can recur clinically, but the recurrence rate is relatively low. There are cases of ovarian teratoma recurrence after teratoma excision surgery. For recurrent teratomas after surgery, it is still recommended to undergo surgical removal again. With an increase in the number of surgeries, the probability of teratoma recurrence gradually decreases. It is recommended that patients who have undergone teratoma surgery undergo regular follow-up examinations.

doctor image
home-news-image
Written by Shen Li Wen
Obstetrics and Gynecology
56sec home-news-image

Do teratomas grow quickly?

Ovarian teratomas are a relatively common type of ovarian tumor and belong to germ cell tumors. Depending on the benign or malignant nature of the teratoma, their differentiation and growth rates vary, meaning they grow at different speeds. For instance, benign teratomas, also known as mature teratomas, usually grow slowly. Many women may find that, upon having a check-up every six months or a year, the size of the teratoma remains the same with no significant changes. However, some women may have malignant teratomas, or their previously mature teratomas may become malignant. In such cases, the mass may suddenly increase in size over a short period, causing abdominal pain, and sometimes the mass can be felt in the abdomen.

doctor image
home-news-image
Written by Shen Li Wen
Obstetrics and Gynecology
1min 13sec home-news-image

What is the cause of the pain from a teratoma?

Female teratomas are cystic-solid tumors located on the ovaries. When they are small in size, they generally do not cause pain. However, as they grow larger, due to gravitational pull, they stretch the surrounding ligaments, causing women to experience hidden pain on one side of the lower abdomen. This pain is bearable and only intensifies after vigorous activities or intercourse. Some women may experience increased pain if they have a pelvic infection or during menstruation. Because teratomas are uneven in texture, if they are not adherent to surrounding structures and are relatively mobile, and their stalk is thinner, they might twist under certain circumstances, such as rolling over, spinning hula hoops, or during pregnancy, when the uterus grows and changes the position of the teratoma, leading to acute lower abdominal pain from torsion of the teratoma’s stalk. Therefore, when a woman experiences abdominal pain from a teratoma, it is essential to conduct a gynecological examination and pelvic ultrasound to understand the specific cause of the pain.

doctor image
home-news-image
Written by Li Shun Hua
Obstetrics and Gynecology
52sec home-news-image

Can women with ovarian teratomas have children?

Ovarian teratomas, if discovered after pregnancy, do not significantly impact the child; however, it's crucial to confirm that the ovarian teratoma is benign. If detected during pregnancy, close observation is possible, and sudden lower abdominal pain may indicate ovarian torsion, which requires timely surgical intervention. If there are no symptoms, surgery can wait until after the child is born. If an ovarian teratoma is discovered before pregnancy, it is advisable to undergo surgery before becoming pregnant because ovarian teratomas can sometimes be malignant, and torsion may occur during pregnancy, which could affect the child.

doctor image
home-news-image
Written by Shen Li Wen
Obstetrics and Gynecology
55sec home-news-image

What's the matter with ovarian teratoma pain?

The causes of lower abdominal pain in women with ovarian teratomas are complex. Firstly, as the teratoma grows in size, it can, due to gravity, pull on surrounding ligaments, causing pain on one side of the lower abdomen. When the teratoma is particularly large, it can also compress nerves in the pelvis, leading to neuropathic pain. Moreover, teratomas are heterogeneously textured. If they are quite mobile and not adhering to surrounding tissues, sudden changes in body position, or an increase in uterine size during the mid-pregnancy, might shift the position of the teratoma. This can lead to torsion of the stalk, causing local ischemia and hypoxia, and resulting in acute lower abdominal pain.