Patients with oral cancer presenting with facial perforation symptoms can be treated with the following clinical methods: First, local dressing changes should be performed on the perforated facial tissue. Topically applied antibiotics can be used to prevent and treat infections caused by the perforation. Additionally, topical anesthetics can be applied to alleviate pain. Second, as facial perforations are often due to cancerous tissue damage, considering the application of topical chemotherapy drugs can promote the shrinkage of cancerous lesions at the perforation site, which is beneficial for the growth of normal tissues.