Is melanoma cancer?

Written by Sun Ming Yue
Medical Oncology
Updated on September 25, 2024
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Melanoma is generally a malignant tumor caused by melanin in the skin and other organs, which means melanoma is also known as cancer, and it is a very bad tumor. If there are hair follicles in this melanoma, then it is very likely that cancerous changes will occur. Patients should pay attention as the malignancy of the disease is extremely high, and they should seek timely medical examinations and treatment.

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Written by Liu Jing
Dermatology
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How to diagnose melanoma

For the judgment of melanoma as a malignant tumor, it cannot solely rely on clinical experience. Instead, the skin lesion should undergo surgical excision. During the surgery, freezing can be scheduled, and the results of the freezing report will determine the scope of the surgery. The final diagnosis still depends on the paraffin section. The diagnostic gold standard is based on the pathological results, and only a pathology examination can determine whether the lesion is a malignant melanoma. Diagnosing such diseases requires extreme caution due to their high malignancy and ease of metastasis, which can endanger life. Standardized surgical excision is necessary, supplemented by chemotherapy and other methods.

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Melanoma CT manifestations

The CT manifestations of melanoma vary depending on the location of the tumor. Generally, melanomas that occur on the skin can appear on CT scans as mass-like lesions, and the scans can show whether there are any urgent conditions involving the surrounding nerves, blood vessels, and tissues. Some patients may only show CT imaging changes such as localized thickening of the skin. In melanomas that occur inside the skull or in the vulva, the CT mainly shows localized mass-like lesions. These lesions are typically low-density foci with poor blood supply around them, and they generally have an irregular shape.

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Written by Liu Gang
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Does melanoma need to be excised?

Melanoma is a type of malignant tumor, which mostly develops from common melanocytic nevi. Once diagnosed with this disease, surgical removal is necessary. After the surgery, a full-body examination is also required to check whether the tumor cells have metastasized. If there is metastasis, further radiotherapy or chemotherapy is needed. If melanocytic nevi appear on the body, it is crucial to handle them properly, ideally by using laser treatment or surgical removal when they are relatively small to prevent the later formation of melanoma. If the melanocytic nevi cause pain, itching, or oozing after scratching, it might be a precursor to malignancy, and formal treatment is necessary.

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Written by Cui Fang Bo
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Can melanoma without metastasis avoid chemotherapy?

For patients with melanoma that has not metastasized, direct surgical removal can be performed, and chemotherapy is not necessary after surgery. Melanoma is a malignant tumor that originates from melanocytes and can occur in many parts of the body, with melanomas of the skin and mucous membranes being the most common, accounting for about 70% of all cases. Once melanoma is diagnosed, if there is no distant metastasis to other organs, curative surgical removal can be performed. Postoperative treatment mainly involves immunotherapy, not systemic chemotherapy. For patients who are diagnosed with distant organ metastasis, systemic chemotherapy and immunotherapy are required.

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The significance of melanoma genetic testing

The significance of genetic testing for melanoma patients mainly involves two aspects: first, the identification of specific driver gene mutations to guide the application of targeted drugs; second, the detection of mutations in some common genes to judge the prognosis of the disease. Regarding the target gene mutations for drug selection, the commonly used ones include mutations in C-KIT, BRAF, and M-TOR. If mutations in these target genes are found, corresponding targeted drugs can be used for treatment. These drugs are generally orally administered, have relatively good efficacy, low side effects, and are suitable for the treatment of melanoma. Additionally, some genetic tests can predict the prognosis of melanoma patients based on the presence or absence of mutations.