symptoms of melanoma bone metastasis

Written by Sun Ming Yue
Medical Oncology
Updated on September 01, 2024
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Once melanoma metastasizes, patients will experience significant pain, which will become increasingly severe and eventually unbearable. Having melanoma can also cause the bones to become brittle and prone to fractures and cracks. Once melanoma metastasizes, it also destroys the body's immune system, causing patients to suffer from long-term headaches and nausea, and making the body weaker.

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Stage IV melanoma is what stage?

Melanoma stage IV is stage 4, where IV is the Roman numeral for 4. Stage IV melanoma means that the melanoma is no longer confined to the site of origin and has metastasized to distant organs. Melanoma commonly originates in the skin and mucous membranes, with the most common sites of metastasis being the lymph nodes and lungs. Once melanoma reaches stage 4, the opportunity for curative surgery is lost. Treatment primarily involves immunotherapy, targeted molecular therapy, etc., and is incurable.

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Can melanoma without metastasis avoid chemotherapy?

For patients with melanoma that has not metastasized, direct surgical removal can be performed, and chemotherapy is not necessary after surgery. Melanoma is a malignant tumor that originates from melanocytes and can occur in many parts of the body, with melanomas of the skin and mucous membranes being the most common, accounting for about 70% of all cases. Once melanoma is diagnosed, if there is no distant metastasis to other organs, curative surgical removal can be performed. Postoperative treatment mainly involves immunotherapy, not systemic chemotherapy. For patients who are diagnosed with distant organ metastasis, systemic chemotherapy and immunotherapy are required.

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Is melanoma flat or raised?

Melanoma generally is not flat, also known as malignant melanoma, which is a highly malignant cancer originating from melanocytes, commonly occurring in the skin. Men over the age of 60 are a high-risk group, with the most commonly affected areas being the lower limbs and feet, followed by the trunk, head and neck, or upper limbs. Symptoms mainly include rapidly growing melanotic nodules. Initially, normal skin becomes heavily pigmented, or pigmented moles darken and increase in pigment. The skin lesions continually enlarge and harden, accompanied by itching and pain. The lesions of melanoma may be raised, patchy, or nodular, and some may even resemble cauliflower.

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Is it better for melanoma to have a BRAF mutation or not to have a BRAF mutation?

Melanoma is a type of skin cancer with a very high malignancy. Before targeted drugs were available, patients with BRAF gene mutations indicated a poorer prognosis for melanoma. The mutation of the BRAF gene promotes the progression of melanoma. However, with the advancement of current clinical research, patients with melanoma having BRAF mutations have a better therapeutic effect with BRAF inhibitor targeted therapy. After adopting this targeted drug treatment, the cure rate has significantly increased, and the prognosis of patients has markedly improved. Therefore, patients with BRAF-mutated melanoma can benefit from targeted therapy.

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Is melanoma flat or raised?

Melanoma is generally raised and does not have a fixed shape. In the early stages of local growth, melanoma appears flat. As the tumor grows and proliferates, some protrusions may occur, but protrusions should not be equated with malignancy. If a previously flat mole suddenly becomes raised, one should be vigilant about the possibility of malignancy. However, a raised mole is not necessarily melanoma; there are some intradermal nevi or benign skin lesions, and other types of skin cancers can also manifest as raised changes. Therefore, if there are some melanocytic nevi on the skin that quickly develop symptoms such as ulceration, bleeding, pain, or itching, it is important to promptly visit a dermatology department at a standard hospital for an examination and, if necessary, surgical removal and pathological investigation.