What are the symptoms of osteosarcoma?

Written by Wang Cheng Lin
Orthopedics
Updated on January 10, 2025
00:00
00:00

Symptoms of Osteosarcoma:

The first is pain at the site of occurrence. This pain may be intermittent and not very pronounced in the early stages. As the condition progresses, the severity of the pain gradually increases, transitioning from intermittent to persistent pain;

The second is the formation of a lump. You can feel a lump on the limb with your hand, and this lump is clearly tender to the touch;

The third is limping, which is mainly caused by the pain in the limb;

The fourth is the most common systemic symptoms. Patients with this malignant tumor will exhibit fever, weight loss, anemia, and pathological fractures.

These are the main symptoms of osteosarcoma currently observed in clinical settings.

Other Voices

doctor image
home-news-image
Written by Wang Cheng Lin
Orthopedics
38sec home-news-image

Osteosarcoma common onset age

Osteosarcoma most commonly occurs in adolescents under the age of 20, or in children, and is a type of malignant tumor. It is the most common malignant bone tumor in children, accounting for about 5% of all malignant tumors in children, making this age group highly susceptible to osteosarcoma. The formation of osteosarcoma is mainly due to external factors such as viral infections and genetic mutations that lead to cell mutations. Osteosarcoma is a typical malignant tumor that destroys bone and surrounding soft tissue, leading to pathological fractures. It can also form distant metastases, thus posing a significant threat.

doctor image
home-news-image
Written by Na Hong Wei
Orthopedics
59sec home-news-image

Osteosarcoma is a type of cancer.

Osteosarcoma is a relatively common type of malignant bone tumor in clinical practice. It mainly occurs near the ends of the humerus, including the area around the head of the humerus, and at the distal end of the femur, near the femoral condyles, as well as the proximal tibia, close to the tibial plateau. These are its common sites. It predominantly affects teenagers, generally those under 18 years of age. The main symptoms include: firstly, persistent and worsening pain that gradually intensifies and does not alleviate, with the notable characteristic being that the pain is more severe at night than during the day; secondly, the appearance of spindle-shaped tumors around the joints, particularly at the three aforementioned common sites, often accompanied by redness, warmth, pain in the superficial skin, and even prominent superficial veins; thirdly, osteosarcoma is a type of malignant tumor, classified as grade 2B among malignant tumors. Its main feature, apart from local symptoms, is its propensity for metastasis, with the lungs being the most likely site of metastasis.

doctor image
home-news-image
Written by Na Hong Wei
Orthopedics
1min 8sec home-news-image

Is osteosarcoma treatable?

Osteosarcoma is not about whether it can be treated, but it must be treated. Moreover, the earlier the treatment, the higher the five-year survival rate. Currently, the treatment for osteosarcoma still primarily involves comprehensive therapy centered around surgery. With the advent of neoadjuvant chemotherapy, the five-year survival rate for osteosarcoma has significantly increased. Specifically, once osteosarcoma is diagnosed, extensive chemotherapy is administered before surgery. After chemotherapy, depending on the extent of tumor invasion, either radical segmental resection, limb-sparing surgery, or amputation is considered. Postoperative treatment also requires continued high-dose chemotherapy. In fact, if osteosarcoma is not treated, it metastasizes very quickly, primarily to the lungs. However, if the treatment is very early, timely, and correct, the current five-year survival rate has reached about 80%. Therefore, osteosarcoma can be treated, and the earlier the treatment, the better the outcomes.

doctor image
home-news-image
Written by Na Hong Wei
Orthopedics
58sec home-news-image

Osteosarcoma mainly metastasizes through

The main metastatic pathways of osteosarcoma are generally divided into three types. The first is hematogenous spread, which refers to the dispersal of tumor cells throughout the body via the bloodstream, typically settling in areas with slower blood flow which facilitates the deposition of these cells leading to local changes. The second is direct implantation, which involves tumor cells directly establishing themselves in the vicinity of the tumor's common sites, eventually leading to local metastasis. The third type is lymphatic spread, where tumor cells migrate through the lymphatic system, spreading along lymphatic vessels or pathways. Therefore, the main metastatic pathways of osteosarcoma are these three types. The primary sites of metastasis for osteosarcoma are mainly the lungs, but metastases can also occur in the brain or through other mechanisms.

doctor image
home-news-image
Written by Guan Yu Hua
Orthopedic Surgery
1min 14sec home-news-image

During the treatment of osteosarcoma

Osteosarcoma is a highly malignant tumor of the bone, primarily presenting with pain, elevated skin ridges, and bulging veins. Radiological examination often reveals bone abnormalities, such as Codman's triangle and periosteal reactions due to sun exposure. If there is no metastasis in the early stages, limb amputation surgery can be performed, as well as limb-sparing surgeries involving devitalization and reimplantation or prosthetic implantation. Post-operative treatment involves high-dose chemotherapy, which can inhibit the growth of the bone tumor and extend the patient's survival time. There is a high probability of lung metastasis occurring in the early stages of the disease. If metastasis occurs, the survival time may be significantly reduced. Early diagnosis of this disease is crucial, and it must be treated with chemotherapy as early as possible. With the rapid development of chemotherapy, the five-year survival rate for osteosarcoma can increase to over 50%. Thus, early detection, early treatment, early surgery, followed by chemotherapy and radiotherapy are essential to prolong the patient's survival time.