Osteosarcoma can exhibit which symptoms?

Written by Wang Cheng Lin
Orthopedics
Updated on March 27, 2025
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The symptoms of osteosarcoma, first of all, include pain. The severity of the tumor varies, and so does the accompanying pain. If the tumor significantly damages the bone, causing stimulation to the nerve endings of the periosteum, it will lead to increased pain;

Secondly, there is a lump. A lump can be felt on the limb, but this lump also comes with significant tenderness. The growth rate of this lump depends on the condition;

Third, there is limping. This limping is also due to limb pain, which causes progressive limping symptoms when walking, and prolonged limping can also lead to joint stiffness and muscle atrophy;

Fourth, there are systemic symptoms. Any patient with malignant tumors will experience weight loss, anemia, and multi-organ failure, and may even suffer from pathological fractures.

Other Voices

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Written by Guan Yu Hua
Orthopedic Surgery
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Osteosarcoma Causes

Osteosarcoma is the most common malignant tumor of the bone and typically presents without symptoms in its early stages. The cause of osteosarcoma is unknown, and it often goes undetected until it has reached a moderate or advanced stage. It commonly develops at the distal end of the femur near the knee joint, at the proximal end of the tibia, or at the proximal end of the humerus, primarily at the end of the growth plate. The pain associated with osteosarcoma is usually persistent, especially severe at night, and can lead to symptoms such as anemia or general wasting. The tumor's surface may be warm to the touch, with prominent veins visible, and radiographic imaging might show a Codman's triangle, indicative of sunlight-like radiation patterns, as well as bone destruction and clear periosteal reaction. Surgical treatment is typically pursued, with amputation being the most common procedure, though limb-sparing surgeries are possible if the tumor is detected early enough. Some cases metastasize, most commonly to the lungs, requiring continued high-dose chemotherapy post-surgery to prolong survival. Generally, the five-year survival rate for osteosarcoma can exceed 50% with early diagnosis and treatment. The chances of survival heavily depend on the individual’s constitution, the timing of tumor detection, and the surgical intervention. The exact causes of osteosarcoma are unclear, and the potential for metastasis complicates treatment. Therefore, early surgical intervention is crucial for improving survival rates and enabling patients to maintain a normal life and work activities.

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Written by Wang Cheng Lin
Orthopedics
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Do benign osteosarcomas use chemotherapy?

First of all, all osteosarcomas are malignant; osteosarcoma is a type of malignant tumor with no benign variant. Regarding the treatment of osteosarcoma, the first step is chemotherapy. After confirming the diagnosis through pathological examination and confirming it is osteosarcoma, The first step is chemotherapy, which can stabilize the tumor cells; Then, the main tissue is surgically removed, as well as the surrounding infiltrated soft tissue; The third step is to use chemotherapy again to eliminate the residual cancer cells. This treatment protocol of chemotherapy-surgery-chemotherapy is currently the most common and advanced method in the country. It can significantly improve the patient's survival rate, reduce the risk of amputation, and can also prevent the recurrence of osteosarcoma.

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Written by Kuang Tao
Orthopedics
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The main metastasis pathways of osteosarcoma

Osteosarcoma is a primary tumor of bone tissue. The tumor can metastasize through the bloodstream, lymphatic system, or nearby tissue. The most common site of metastasis for osteosarcoma clinically is to the lungs. Therefore, it is often recommended that patients undergo chest X-rays or even chest CT scans to detect any metastasis to the lungs.

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Written by Dai Ru
Orthopedics
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Is osteosarcoma bone cancer?

Osteosarcoma is a type of malignant tumor that originates from the bone. Bone cancer is a common term used by people to refer to bone tumors. The terms cancer and sarcoma are different mainly because of their different origins. Cancer primarily originates from epithelial tissue, such as liver cancer, lung cancer, etc. Because bones consist of mesenchymal cells, malignant tumors of the bone are called osteosarcomas, not bone cancer. Osteosarcomas commonly occur in children and adolescents and are a highly malignant type of bone tumor that require prompt treatment once diagnosed.

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Written by Guan Yu Hua
Orthopedic Surgery
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Can late-stage osteosarcoma be cured?

For osteosarcoma in its late stages, it often metastasizes to other organs, with the majority of cases involving lung metastasis. In such cases, conservative treatment can be applied. However, if surgery is an option, it is the best approach as it can be complemented with postoperative chemotherapy and radiotherapy to extend the patient’s survival time. If there is distant metastasis and the body is in poor condition, unable to withstand surgery, then only conservative treatment and nutritional support are viable, along with the use of painkillers. In late stages, when the patient cannot tolerate surgery, only conservative treatment is available with no other alternatives. Typically, the conditions are divided into three stages. By stage three, there is usually lung metastasis. This stage often involves T which signifies intracompartmental or extracompartmental growth—T2 indicating extracompartmental, typically a marker of an aggressive tumor. Then M represents metastasis, with 0 for none and 1 for presence. So, in cases where distant metastasis occurs, it generally corresponds to stage three, phase B, which involves extracompartmental invasive metastasis. In such cases, even surgery provides poor outcomes. Early detection and treatment are best. If it progresses to later or final stages, treatment is often deemed unnecessary, limited to conservative management, as surgical outcomes are poor, and metastasis may occur elsewhere.