Is chondrosarcoma cancer?

Written by Peng Li Bo
Oncology
Updated on September 18, 2024
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Chondrosarcoma is broadly cancer, but in medical terms, we wouldn’t necessarily phrase it that way; we simply describe chondrosarcoma as a type of malignant tumor, and currently, its treatment outcomes are not very good. Generally, when we talk about cancer, we’re referring to malignant tumors that originate from epithelial tissue, including cancers like stomach cancer, lung cancer, colon cancer, and liver cancer, which all derive from epithelial tissues. However, because chondrosarcoma originates from mesenchymal tissue, which includes muscle, cartilage, blood vessels, and nerves, malignant tumors that occur in these areas are usually called sarcomas. Sarcomas are definitely malignant, but to strictly call them cancer is not particularly precise.

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Characteristics of bone metastasis in osteosarcoma

Osteosarcoma, when it metastasizes to the bone, is very complex to treat. Surgery cannot fully excise the metastasized bone tissue. Currently, clinical treatments mainly involve a comprehensive approach using radiotherapy, chemotherapy, and traditional Chinese medicine. Most osteosarcomas show improvement in symptoms and an increase in patients' quality of life after radiotherapy and chemotherapy treatment. However, these treatments have their complications. For instance, while killing tumor cells, they can also damage normal cells, resulting in a decreased immune response and various related complications. Ultimately, this might lead to the cessation of radiotherapy and chemotherapy treatments. Therefore, current treatments for bone metastases from osteosarcoma involve using radiotherapy and chemotherapy in conjunction with traditional Chinese medicine. Traditional Chinese medicine may enhance the efficacy of radiotherapy and chemotherapy while also reducing their toxicity. (The use of medications should be under the guidance of a professional doctor.)

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Written by Na Hong Wei
Orthopedics
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What is osteosarcoma?

Osteosarcoma is a type of malignant tumor that occurs in the bones, generally classified as stage IIb. Common sites for osteosarcoma include the distal part of the bone, the proximal tibia, and the proximal humerus. It most commonly affects adolescents. Clinically, it primarily presents as persistent pain, including nighttime pain. Swelling and limited joint function typically occur around the common sites. Additionally, there are general symptoms associated with cachexia, such as malnutrition, anemia, mild or high fever, or weight loss. Fourthly, it is very prone to causing pathological fractures. Many osteosarcoma patients seek medical attention due to these fractures. Thus, osteosarcoma is a serious malignancy in the bones with a generally poor prognosis. Diagnosis and treatment of osteosarcoma are crucial; upon confirmation, timely treatment is necessary. The primary treatment approach is a combination therapy centered around surgery, typically involving preoperative chemotherapy, followed by surgical treatment and postoperative chemotherapy. Currently, the five-year survival rate for osteosarcoma has significantly improved, reaching approximately 70% to over 80%.

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Written by Wang Cheng Lin
Orthopedics
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Causes of Osteosarcoma Formation

The causes of osteosarcoma formation are currently unclear in clinical practice, but they are somewhat related to environmental factors and genetic changes, including heredity. If triggered by external viral infections or physical and chemical influences, osteosarcomas may develop. Likewise, genetic mutations and cellular mutations might also be associated with the formation of osteosarcomas. Osteosarcomas originate from mesenchymal cells and can grow rapidly; passing through a cartilaginous stage, they directly and indirectly form bone-like and bone tissues, damaging the bone structure, which leads to severe consequences.

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Written by Guan Yu Hua
Orthopedic Surgery
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Why does osteosarcoma not hurt?

Osteosarcoma usually presents with pain, which is often severe, persistent, and most pronounced at night. The local skin temperature may also increase, accompanied by venous obstruction. It is a malignant tumor of the bone, most commonly located near the proximal part of the tibia or the distal part of the femur. The main symptom is pain, and a definite diagnosis can be made through radiographic examination, such as sunlight exposure, Codman's triangle, etc. In its early stages, osteosarcoma can metastasize. If there is no pain, it may be due to individual variations in the disease. However, the first symptoms of malignant bone tumors are usually pain and a palpable mass. Radiographic examinations will show changes. If osteosarcoma is confirmed and there is no pain, it could be related to the disease not having progressed to a more severe stage, possibly indicating an early stage. Early aggressive surgical treatment is recommended, such as limb-sparing surgery, devitalization and reimplantation, or prosthetic implantation. Another option is amputation. Osteosarcoma has a relatively high chance of metastasizing to the lungs; therefore, early surgery, early diagnosis, and rapid chemotherapy are essential, as these can significantly increase the five-year survival rate.

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Does osteosarcoma spread through blood?

As far as we know, osteosarcoma is not transmitted through blood or infectious. If osteosarcoma had such infectious characteristics, it would be transmitted in the same way as AIDS or other sexually transmitted diseases and would be classified as a contagious disease. However, there has been no notification or relevant guidelines to date indicating that osteosarcoma can be transmitted through blood. Therefore, normal contact with patients with osteosarcoma, or caring for patients with osteosarcoma, including sharing the same food or coming into contact with their blood, generally does not lead to the transmission or contraction of osteosarcoma.