Early symptoms of syphilis in men may include small papules, with the characteristic lesion of early syphilis being a chancre. From the infection with the syphilis spirochete to the appearance of skin symptoms, it usually takes about three weeks on average.

The syphilis chancre in men is typically found on the genitals, though a minority may appear in the mouth. The earliest form of a chancre is a solitary papule, which gradually develops into a round or oval-shaped ulcer. The ulcer has clear boundaries, slightly raised edges, and a clean base, feeling firm like cartilage to the touch, without significant pain.

When a chancre appears, if a secondary bacterial infection occurs, pain may arise. Men infected with syphilis must seek early treatment as early-stage syphilis can be completely cured.