Tetanus shots are administered in the buttocks or the muscular part of the upper arm, typically given as a muscle injection. Tetanus shots must not be administered intravenously. Before administering a tetanus shot, a skin test is conducted. If the skin test is positive, it is necessary to switch to a tetanus immune globulin that does not require a skin test; if the skin test is negative, a muscle injection can be performed. Tetanus is caused by the colonization of Clostridium tetani in the human body, producing neurotoxins, leading to a specific type of infection. Therefore, if the wound is deep and heavily contaminated, it is essential to promptly treat with a tetanus shot.