Reflux esophagitis, if accompanied by fever, might indicate the possibility of an infectious disease. It is necessary to further determine whether there is an infection and its location. Complete blood count and C-reactive protein tests can be conducted. At the same time, a follow-up gastroscopy should be done to observe the condition of the esophageal lesions, and histopathological examinations might be necessary when needed. Patients with reflux esophagitis require active treatment to suppress gastric acid secretion, and can also use gastroprotective agents, such as magnesium trisilicate and sucralfate. Prokinetic drugs like mosapride and itopride are also needed for treatment. Dietary adjustments should focus on a bland diet, avoiding spicy and irritating foods.