The destruction of corpus luteum cells can lead to infertility. The most common issue is the obvious rupture of the corpus luteum, accompanied by excessive pelvic fluid, which requires surgical treatment. Post-surgery, there could be pelvic adhesion, leading to partial fallopian tube adhesion, which may result in blockages or obstructions in the fallopian tubes. Therefore, during pregnancy, an ectopic pregnancy may occur, and even infertility, particularly in some women who do not seek timely medical treatment after a corpus luteum rupture. This leads to the spread of pelvic inflammatory disease, which may even develop into chronic pelvic inflammatory disease. It is essential to be cautious and avoid vigorous physical activities to prevent the dangerous rupture of the corpus luteum.