There are many diseases or factors that can lead to male infertility, leading to azoospermia, severe oligospermia, and oligozoospermia, as well as normospermic infertility, polyspermia, asthenospermia, etc. The main causes can be summarized in the following points: First, male sexual dysfunction, such as erectile dysfunction, premature ejaculation, and anejaculation, can all cause male infertility. Second, abnormalities in sperm structure and seminal plasma can affect sperm motility, capacity, and reaction. Third, obstruction of the vas deferens affects the transport of sperm. Fourth, infection of the reproductive tract. Fifth, endocrine disorders, including deficiencies in gonadotropins. Sixth, chromosomal abnormalities, including the common pseudohermaphroditism chromosome.