Will infertility cause amenorrhea?

Written by Zhao Min Ying
Reproductive Medicine
Updated on May 28, 2025
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The WHO defines infertility as the condition when both the husband and wife have no desire to remain childless. If they cohabit for more than a year with normal sexual relations and without taking any contraceptive measures and still fail to conceive, they are diagnosed with infertility. Infertility and irregular menstruation are not related, nor does infertility lead to amenorrhea. Amenorrhea or irregular menstruation is due to endocrine reasons. This requires blood tests for six hormone levels, thyroid function, and some endocrine metabolism indicators. These can cause difficulty in conceiving and lead to ovulation disorders. Infertility does not cause amenorrhea, but if amenorrhea occurs, it might affect pregnancy and lead to infertility. This is the relationship between them.

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Written by Kang Jian Hua
Reproductive Center
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How to cure immune infertility

Immune infertility comes in many forms, such as anti-sperm antibody positivity and anti-endometrial antibody positivity, among others. The treatment for immune infertility commonly involves the use of isolating therapy, which entails using a condom during sexual intercourse. After using this method for three to six months, it can reduce further stimulation of the female by the sperm antigen, and once the antibody effect has dissipated, intercourse is timed with ovulation. At this time, conception is often possible. For immune infertility, some may choose intrauterine artificial insemination depending on the situation, which involves processing and separating the husband's semen outside the body to extract high-quality sperm for intrauterine insemination. Another method is anti-immune therapy, but the medications often have adverse side effects on the body.

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Written by Zhao Min Ying
Reproductive Medicine
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Can sexual apathy cause infertility?

Sexual indifference is a matter concerning the harmony of sexual life between couples, the stability of their relationship, and the quality of life. Regarding fertility, as long as the couple can have sexual intercourse, the male can ejaculate, and the semen can be deposited into the female reproductive tract, there is a chance of pregnancy. Therefore, from this perspective, mere sexual indifference, as long as intercourse can be completed, does not affect conception. However, if sexual indifference prevents intercourse, then it does affect the possibility of pregnancy. Therefore, ultrasound monitoring of ovulation and guiding intercourse during the ovulation period can increase the chances of pregnancy. When necessary, artificial insemination can also be considered to aid conception.

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Written by Yue Hua
Obstetrics and Gynecology
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What are the reasons for infertility despite having intercourse during the ovulation period?

The reasons for not getting pregnant despite having intercourse during the ovulation period primarily involve considering whether there is an issue with the male partner’s sperm. Additionally, although it is the ovulation period, the development of the follicles must also be examined. If the follicles are undeveloped, or if they are very small, pregnancy is unlikely in such cases. Moreover, the condition of the fallopian tubes should be checked, as both the egg and the sperm need to travel through these tubes. If the fallopian tubes are blocked, it will prevent pregnancy because the sperm and egg cannot meet, leading to infertility.

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Written by Kang Jian Hua
Reproductive Center
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What are the routine examinations for infertility?

Infertility examinations typically include physical exams and special tests. Physical exams mainly involve checking the development of internal and external reproductive organs and secondary sexual characteristics. Special tests can include examining the quality of male semen, endocrine conditions, and anti-sperm antibodies. Additional procedures can include scrotal ultrasound, prostate ultrasound, prostate massage fluid analysis, and monitoring of the spermatic veins with ultrasound to check for varicoceles. For females, it is important to check for any underlying diseases and ensure normal development of the uterus, ovaries, and adnexa. Examinations should also check for uterine fibroids, ovarian cysts, and endometriomas, and assess for any abnormalities in the reproductive tract. Monitoring ovulation is also crucial to identify any abnormalities in ovulation. If ovulation is normal, the patency of the fallopian tubes should be checked, which can be done through a fallopian tube iodine contrast imaging procedure.

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What tests are done for secondary infertility?

The most common cause of secondary infertility in women is blocked fallopian tubes. In this case, a hysterosalpingography with iodine oil should be performed to understand the patency of the fallopian tubes and the specific location of the blockage, which can guide future treatment. Additionally, if a woman has abnormal vaginal discharge, a routine gynecological examination should be conducted to check for any cervical lesions. A vaginal secretion test should be performed to see if vaginal inflammation is affecting normal pregnancy. Some women experience infertility after having an abortion or induced abortion, and for these women, it's also worth considering whether uterine issues are causing secondary infertility. A hysteroscopy can be done to investigate this. When a woman experiences secondary infertility, her sexual partner or spouse should also be examined to assess sperm quality and any potential obstacles in the sperm delivery pathway.