The treatment of neurodermatitis consists of three aspects. First, patients should be advised to avoid scratching, rubbing, and other irritations, and appropriate psychological treatment should be provided to interrupt the vicious cycle of itching and scratching. Second, the use of topical medications should be based on the location and characteristics of the rash. Hormonal ointments, anti-itch moisturizing ointments can be rationally selected, and occlusive treatments can be applied in severe cases. If the rash is widespread, treatments such as medicated baths and ultraviolet light exposure may be chosen. Thirdly, the treatment involves systemic medications, mainly including oral antihistamines, calcium supplements, vitamins, and so on.