Neurodermatitis, also known as chronic simple lichen, is a common chronic inflammatory skin disease characterized by episodic intense itching and lichenoid changes in the skin due to neurofunctional impairment. The etiology could be related to various factors including neuropsychiatric factors, gastrointestinal dysfunction, endocrine disorders, diet, and local irritation. In clinical treatment of neurodermatitis, we use topical medications along with oral systemic drugs. Commonly prescribed oral medications include antihistamines and calcium supplements. Additionally, various vitamins such as vitamin C, vitamin B1, vitamin B12, and complex vitamin B are also commonly used in combination.