Chickenpox and hand, foot, and mouth disease are common infectious diseases in young children. Chickenpox is a febrile rash disease caused by the varicella-zoster virus. Its rash mainly manifests as maculopapular, vesicular, and crusted lesions, which appear simultaneously. Generally, these are primarily seen on the face and trunk with a centripetal distribution. Hand, foot, and mouth disease is mainly caused by viruses, such as enterovirus EV71 or Coxsackievirus A16. It causes a febrile rash disease with rashes typically found on the hands, feet, and around the mouth. Rashes on the chest, back, and face are relatively rare. Thus, the main clinical presentations of hand, foot, and mouth disease and chickenpox are the different forms of rashes.