Causes of Alzheimer's Disease in the Elderly

Written by Zhang Hui
Neurology
Updated on September 06, 2024
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The causes of dementia in the elderly are not currently completely clear. Dementia in the elderly is mainly divided into familial and sporadic types. Familial dementia shows autosomal dominant inheritance, which is caused by a gene mutation on chromosome 21 leading to the accumulation of some toxins, resulting in the death of neurons and causing dementia fundamentally due to genetic mutations. However, most cases of dementia are sporadic and do not have a clear family history. The mechanisms and reasons for disease onset are not particularly clear. Some believe that abnormalities in cerebral vascular function may lead to neuronal cell functional disorders, resulting in decreased ability to clear certain cell toxins, thus leading to neuronal apoptosis and death, and consequently impaired cognitive functions. In addition, factors such as oxidative stress, inflammatory mechanisms, excessive fatigue, and emergency stress may also cause cell death. Overall, the causes of dementia in the elderly are not particularly clear.

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Written by Zhang Hui
Neurology
1min 8sec home-news-image

How is Alzheimer's treated?

The treatment of Alzheimer's disease mainly includes the following aspects. First, enhance care to prevent accidents. Patients with Alzheimer's may get lost, forget to turn off fires or gas, etc., so it is essential to strengthen care to prevent accidents. Second, encourage the elderly to read more books and newspapers and enhance learning, which can effectively slow down the progression. Third, have the elderly interact more with others and exercise more. This can strengthen their physical health and, to some extent, delay the development of Alzheimer's disease. Another aspect is drug treatment, which mainly includes acetylcholinesterase inhibitors and some NMDA receptor antagonists. These can improve the symptoms to some extent and enhance the quality of life. Additionally, in the later stages of Alzheimer's, some psychiatric symptoms such as visual hallucinations and aggressive behavior like hitting or yelling may occur. Appropriate atypical antipsychotic drugs can be administered for treatment.

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Written by Zhang Hui
Neurology
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What to do about senile dementia?

For patients with dementia, if the diagnosis is confirmed, the recommended treatment is as follows: First, it is very important to pay attention to nursing care. Patients with dementia often get lost, which can lead to a series of dangers, so it is necessary to take good care of them to prevent getting lost. Secondly, for the improvement of cognitive functions, it is recommended to use some cholinesterase inhibitors, which can increase the level of acetylcholine in the brain and improve the patient's cognitive functions to a certain extent. Third, symptomatic treatment should also be provided. Since patients with dementia often exhibit psychiatric symptoms, such as visual and auditory hallucinations, appropriate antipsychotic medications can be used for treatment. (Please use medication under the guidance of a professional physician.)

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Written by Tang Li Li
Neurology
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Methods for Examining Dementia in the Elderly

The examination of dementia mainly includes the following aspects. First, it is to determine whether the patient has cognitive impairment, because in the early stages of dementia this impairment is often mild, primarily in recent memory, with other aspects not yet obvious. Early screening can use some cognitive evaluation scales, such as the Mini-Mental State Examination or the Montreal Cognitive Assessment, chosen according to the patient's cultural level. Second, imaging examination, commonly using brain MRI, can reveal significant signs of dementia such as deepened brain sulci, narrowed gyri, and widened lateral fissures, indicating brain atrophy. Third, genetic testing for the APOE gene, which may be related to dementia. Possession of this gene may increase the likelihood of developing dementia in the future, serving as an auxiliary diagnostic measure.

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Written by Zhang Hui
Neurology
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How is Alzheimer's disease treated?

Senile dementia, also known as Alzheimer's disease, is the most common neurodegenerative disease worldwide. The pathogenesis of this disease is not particularly clear so far and may be related to genetic and environmental factors. Multiple factors act on neurons causing irreversible and progressive death of neuronal cells. Currently, the treatment of this disease mainly includes two aspects. The first aspect is general treatment, mainly including family care. Family members must pay attention to the care of the patient, prevent the patient from accidentally wandering off, prevent the patient from falling, and prevent some accidents that cause injuries. In addition, it is important for the patient to listen to music, interact with others, and exercise more, all of which can delay the progression of senile dementia. The second aspect is pharmacological treatment, mainly using drugs that inhibit the reduction of acetylcholine. These drugs can increase the content of acetylcholine and improve the cognitive functions of patients to a certain extent, but so far, these treatments cannot reverse senile dementia.

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Written by Zhang Hui
Neurology
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What to eat for senile dementia

For patients with dementia, it is recommended to take some cholinesterase inhibitors, which can increase the content of acetylcholine in the brain and have certain effects on improving cognitive functions. Additionally, consuming NMDA receptor antagonists can also help improve cognition. In terms of diet, it is advised that patients eat more foods rich in unsaturated fatty acids, such as fish, shrimp, and olive oil. It's also beneficial to consume plenty of fresh vegetables and fruits, which are rich in vitamin C and can help combat oxidative stress. Drinking more milk and eating foods rich in B vitamins, mainly whole grains, is also recommended. (Medication should be used under the guidance of a doctor.)