Causes of Alzheimer's Disease in the Elderly

Written by Zhang Hui
Neurology
Updated on September 06, 2024
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The causes of dementia in the elderly are not currently completely clear. Dementia in the elderly is mainly divided into familial and sporadic types. Familial dementia shows autosomal dominant inheritance, which is caused by a gene mutation on chromosome 21 leading to the accumulation of some toxins, resulting in the death of neurons and causing dementia fundamentally due to genetic mutations. However, most cases of dementia are sporadic and do not have a clear family history. The mechanisms and reasons for disease onset are not particularly clear. Some believe that abnormalities in cerebral vascular function may lead to neuronal cell functional disorders, resulting in decreased ability to clear certain cell toxins, thus leading to neuronal apoptosis and death, and consequently impaired cognitive functions. In addition, factors such as oxidative stress, inflammatory mechanisms, excessive fatigue, and emergency stress may also cause cell death. Overall, the causes of dementia in the elderly are not particularly clear.

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Written by Zhang Hui
Neurology
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progression of Alzheimer's disease in the elderly

The progression of dementia in the elderly mainly includes the following aspects. The first is the pre-stage of mild cognitive impairment, during which patients show no clinical symptoms. Some may only report slight memory impairment, with a possible slight decline in learning ability and a mild decrease in the capability to learn new things. As the disease progresses to the second stage, the period of mild cognitive impairment occurs, where patients will experience impaired memory, but it is not particularly obvious, and daily life is not affected at all. Then, entering the third stage, some periods of dementia occur, during which patients' memory, executive abilities, computational skills, and judgment are significantly impaired. Patients might even get lost or possibly forget their own names. As the disease further progresses into the later stages of dementia, the elderly may exhibit some psychiatric symptoms. They become delirious, talk to themselves, and may see things that do not exist. Eventually, the elderly may end up bedridden, with complications such as pulmonary infections and bedsores.

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Written by Tang Bo
Neurology
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How long is the lifespan of someone with Alzheimer's?

The causes of dementia in the elderly can be varied, with many diseases such as Alzheimer's disease, Parkinson's disease, and vascular dementia, all leading to senile dementia. Therefore, how long one lives may require specific analysis. If the dementia is due to cerebrovascular factors, the lifespan of the individual may be closely related to the primary disease, i.e., cerebrovascular disease. Dementia caused by Alzheimer's disease progresses with the disease and affects the patient's lifespan. In its advanced stages, when the patient can no longer take care of themselves, complications such as lung infections can further impact their lifespan. There are also other factors, which need to be assessed based on the evaluation of the disease.

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Written by Zhang Hui
Neurology
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symptoms of senile dementia

The symptoms of dementia mainly include the following aspects: First, there is evident impairment in cognitive functions, primarily involving memory decline. Initially, it may predominantly affect recent memory, with patients often forgetting recent events. As the disease progresses, they may start forgetting events from the distant past as well. Additionally, patients may experience a decline in calculation skills, judgment, execution, and comprehension abilities; their capacity to learn and work is comprehensively impaired. Spatial dysfunction can also occur, causing disorientation and frequent episodes of getting lost. Secondly, in the later stages, patients may display changes in behavior and personality, alongside corresponding psychological symptoms. For example, the patient might become aggressive, restless, and exhibit hallucinations visually and auditorily. Wandering at night is another common symptom. Thirdly, in the later stages, patients might show clinical signs such as muscle atrophy and paralysis. Incontinence is also a common symptom.

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Written by Zhang Hui
Neurology
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How is Alzheimer's treated?

The treatment of Alzheimer's disease mainly includes the following aspects. First, enhance care to prevent accidents. Patients with Alzheimer's may get lost, forget to turn off fires or gas, etc., so it is essential to strengthen care to prevent accidents. Second, encourage the elderly to read more books and newspapers and enhance learning, which can effectively slow down the progression. Third, have the elderly interact more with others and exercise more. This can strengthen their physical health and, to some extent, delay the development of Alzheimer's disease. Another aspect is drug treatment, which mainly includes acetylcholinesterase inhibitors and some NMDA receptor antagonists. These can improve the symptoms to some extent and enhance the quality of life. Additionally, in the later stages of Alzheimer's, some psychiatric symptoms such as visual hallucinations and aggressive behavior like hitting or yelling may occur. Appropriate atypical antipsychotic drugs can be administered for treatment.

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Written by Zhang Hui
Neurology
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early signs of dementia

Dementia in the elderly, mainly referring to Alzheimer's disease, is primarily characterized by a significant decline in the patient's memory and learning abilities. Of course, there are some prodromal symptoms before the onset of dementia. For example, patients might show no clinical signs of cognitive impairment or only display very slight memory decline. Patients might exhibit mild impairment in memory, a decrease in the ability to learn and retain new information, and mild impairments in other cognitive areas such as attention, executive function, language skills, and visuospatial abilities. However, these impairments are very slight and can go unnoticed by family members. Moreover, these mild impairments do not affect the patient's basic daily life abilities and do not reach the level of dementia. Patients can live independently and manage their routine daily tasks, which are mainly some of the early signs of dementia.