People with AIDS experience itching because pruritus is one of the most common symptoms in AIDS patients. It can occur relatively early in the disease. This type of itching occurs without primary skin rashes and is so severe that it is unbearable. In severe cases, there may be a tendency towards suicide. Therefore, in treatment, we use antihistamines with sedative effects. Oral administration is combined with the external application of moisturizing and anti-itch medications. When necessary, ultraviolet light exposure can be used, or it can be combined with other methods.