Can tuberculosis be fatal? Of course, the answer is yes. Many diseases can lead to death, even a common cold can potentially result in death, let alone tuberculosis, which is an extraordinary illness. Currently, the mortality rate for tuberculosis patients is relatively low because the treatment for tuberculosis has improved significantly compared to the past. However, there are still a small number of patients who, due to untimely treatment of tuberculosis, discontinuation of medications on their own accord or non-compliance with medical advice, or who have other serious underlying diseases, may not tolerate the tuberculosis treatment. As a result, they could potentially die from adverse reactions to the tuberculosis medications.