Does tuberculosis cause fever? Certainly, fever can occur. Fever is one of the most common clinical manifestations of tuberculosis, which can be mild or high fever. Most cases of tuberculosis mainly present as afternoon febrile flushes, or say, an evening low-grade fever. In a few cases, such as infectious pneumonia or more severe infections like tuberculous pleurisy, there can be high fever, and these fever episodes may last a long time and be recurrent, making them difficult to control.