The white substance in acne is mostly formed by the normal secretions of sebaceous glands accumulating at the mouth of hair follicles, combined with the fermentation of Propionibacterium acnes or Staphylococcus aureus, resulting in pus. Some of the white substances appear as tofu-dregs-like, which are pus formed after vigorous secretion of the sebaceous glands and then absorbed and dried. These substances can be treated with oral and topical anti-inflammatory medications. During treatment, it is also important to regulate one's diet and lifestyle habits, avoiding spicy and stimulating foods to reduce sebum secretion. It is also helpful to avoid staying up late, anxiety, and stress to alleviate symptoms or prevent recurrence.