Pneumothorax is a relatively common clinical condition, usually caused by a rupture of the pleura, allowing air to enter the pleural cavity. Patients often experience symptoms such as chest pain, difficulty breathing, and coughing. So, can someone with pneumothorax fly on an airplane? Patients with pneumothorax are prohibited from flying because the high altitude may aggravate the condition, leading to serious consequences. Even after pneumothorax has healed, it is advised not to fly within a year, as flying may cause the pneumothorax to recur.