How to maintain health with nephrotic syndrome

Written by Zhou Qi
Nephrology
Updated on May 03, 2025
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Patients with nephrotic syndrome should pay attention to maintenance because nephrotic syndrome is a chronic disease. Even if the condition is well controlled, it can still recur or worsen under certain circumstances. First and foremost, patients should avoid various inflammations, including infections of the upper respiratory tract, enteritis, skin infections, ulcers, etc. Patients should avoid getting cold, avoid contact with people who have colds, and wear masks in crowded places. Avoid eating raw, unhygienic food to prevent diarrhea and enteritis. Patients should also limit their salt intake, and it is recommended that their daily salt intake be controlled between 3 and 6 grams.

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Written by Li Liu Sheng
Nephrology
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Conditions for discontinuing medication for nephrotic syndrome

The main clinical manifestations of nephrotic syndrome are significant proteinuria and hypoproteinemia, along with varying degrees of hyperlipidemia and edema. Nephrotic syndrome often requires treatment with corticosteroids. The general principle for using steroids is to start with a sufficient dosage and administer it slowly, maintaining it for a long duration, approximately around one year. Therefore, the conditions for discontinuing medication in nephrotic syndrome include: if the patient has been treated with steroids for about a year, and the proteinuria has resolved, 24-hour urinary protein quantification is normal, there is no edema, blood albumin levels have returned to normal, and kidney function is also normal, then discontinuation of steroid treatment can be considered. Of course, after stopping the medication, it is essential to regularly visit the hospital for monitoring of routine urine tests, kidney function, and blood pressure to prevent the recurrence of nephrotic syndrome due to infections or fatigue.

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Written by Zhou Qi
Nephrology
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Is nephrotic syndrome nauseating?

Nephrotic syndrome generally does not cause symptoms of nausea. Nephrotic syndrome refers to the damage to the glomerular capillaries of the patient, with the patient's 24-hour urinary protein quantification exceeding 3.5 grams, which indicates a substantial presence of urinary protein. This disease can cause edema in various parts of the body, such as the lower limbs, eyelids, and facial area. However, it generally does not cause digestive symptoms such as nausea and vomiting. If a patient exhibits such symptoms, it is necessary to be cautious as it may indicate the onset of acute renal failure due to nephrotic syndrome, or the presence of acute inflammation in the gastrointestinal tract. Patients with nephrotic syndrome generally may experience edema in the gastrointestinal tract, which could cause nausea, and it is important to be cautious of the possibility of other underlying causes.

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Written by Niu Yan Lin
Nephrology
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Does nephrotic syndrome require a puncture?

Nephrotic syndrome is a complex of clinical symptoms with various causes, which differ by age group. In children or adolescents, if it presents solely as significant proteinuria without elevated creatinine or hematuria, it is generally caused by minimal change disease. Since this type of kidney disease is sensitive to hormone treatment, it is usually possible to forego renal biopsy and start with corticosteroid therapy. For other nephrotic syndrome patients, it is advisable to first perform a renal biopsy to identify the pathological cause before considering appropriate treatment with hormones, immunosuppressants, and other medications.

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Written by Zhou Qi
Nephrology
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Manifestations of recovery from nephrotic syndrome

In principle, there is no concept of complete recovery for nephrotic syndrome. The condition of nephrotic syndrome can be alleviated and controlled to the greatest extent, but it cannot be completely cured. When the condition is alleviated, the patient's glomerular filtration barrier is repaired, resulting in a reduction in proteinuria and a decrease in urinary foam clinically. Once the patient's urinary protein decreases, the plasma protein concentration will gradually increase. Thus, water moves back from outside to inside the blood vessels, leading to a reduction in edema. These clinical signs all indicate an improvement in the condition of nephrotic syndrome. Of course, to assess the condition, it is still necessary to rely on the patient undergoing a 24-hour quantitative urine protein test.

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Written by Zhou Qi
Nephrology
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Is nephrotic syndrome prone to recurrence?

Nephrotic syndrome is characterized by more than 3.5 grams of proteinuria in 24 hours and a serum albumin concentration lower than 30 grams per liter. Treatment of this disease should be aimed at the cause, with most patients suffering from primary nephrotic syndrome related to immune dysfunction, therefore often requiring treatment with steroids. Indeed, some patients easily experience relapses; after a period of steroid treatment, proteinuria may decrease or even turn negative. However, upon cessation of the medication or during occurrences like a cold, some patients may suffer from relapses. Not all patients respond this way, as some are dependent on steroids.