Mitral valve regurgitation with calcification indicates the onset of calcification in this condition, though this alone does not necessarily indicate a problem. However, mitral valve regurgitation should still be actively treated. Early or mild cases can lead to pathological changes in the heart, particularly when there is excess pressure on the mitral valve, left ventricle, or left atrium. This may cause symptoms like palpitations, chest tightness, and difficulty breathing. Sometimes, medications to dilate blood vessels, strengthen the heart, and promote urination may be necessary to reduce cardiac load and improve symptoms.