Breast swelling, pain, and coldness are considered to be related to breast hyperplasia, which is often thought to be associated with endocrine disorder causing increased estrogen levels. Local hot compresses, traditional Chinese medicine treatments, and methods to soothe the liver and regulate the Qi to harmonize the Chong and Ren meridians can alleviate pain. Endocrine treatments are also an option, but they could increase the risk of endometrial cancer, thus they are best avoided if possible. However, for prominent pain during the premenopausal phase, it is advisable to take medication before the onset of menstruation. Micronutrient treatments, including vitamins B, C, and E, can be used. These vitamins help improve liver function, regulate hormone metabolism, and enhance autonomic nervous system function, serving as adjunctive medications for this condition. Vitamin E also helps in alleviating pain.