Aplastic anemia is classified into several types.

Written by Li Fang Fang
Hematology
Updated on September 01, 2024
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Aplastic anemia is divided into two types: acute aplastic anemia and chronic aplastic anemia.

Acute aplastic anemia presents suddenly and is severe. Treatment requires intensified immunotherapy or suppression of hematopoietic stem cell transplantation. Chronic aplastic anemia develops slowly, has a longer history, and is relatively less severe. The treatment for chronic aplastic anemia mainly involves immunotherapy combined with therapy to promote hematopoiesis.

In addition, regardless of the type, all cases of aplastic anemia require regular complete blood count checks and, when necessary, supportive treatment with red blood cell and platelet transfusions.

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Written by Li Fang Fang
Hematology
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Is aplastic anemia leukemia?

Aplastic anemia is not leukemia, but there is a very small chance that aplastic anemia can transform into leukemia. Aplastic anemia is a bone marrow failure syndrome, and its clinical presentation often includes pancytopenia. It can be classified into acute aplastic anemia and chronic aplastic anemia. Leukemia often manifests with high white blood cell counts, anemia, and low platelet counts. It is caused by the infiltration of leukemia cells into the bone marrow, leading to the suppression of normal hematopoiesis, and is classified as a malignant hematological tumor. Leukemia can be divided into acute leukemia and chronic leukemia.

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Written by Li Fang Fang
Hematology
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Aplastic anemia is classified into several types.

Aplastic anemia is divided into two types: acute aplastic anemia and chronic aplastic anemia. Acute aplastic anemia presents suddenly and is severe. Treatment requires intensified immunotherapy or suppression of hematopoietic stem cell transplantation. Chronic aplastic anemia develops slowly, has a longer history, and is relatively less severe. The treatment for chronic aplastic anemia mainly involves immunotherapy combined with therapy to promote hematopoiesis. In addition, regardless of the type, all cases of aplastic anemia require regular complete blood count checks and, when necessary, supportive treatment with red blood cell and platelet transfusions.

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Written by Li Fang Fang
Hematology
51sec home-news-image

The etiology of aplastic anemia

The etiology of aplastic anemia currently has no absolute cause, but the more supported theories concerning its etiology include the soil, pest, and seed theories. The soil theory refers to abnormalities in the microenvironment within the bone marrow, which causes an abnormal growth environment for hematopoietic stem cells, consequently limiting their growth. The seed theory indicates a decrease in the number and quality of hematopoietic stem cells in the bone marrow, leading to bone marrow regeneration failure. The pest theory refers to immunological factors, which play a significant role in aplastic anemia, suggesting a disorder in the patient's immune function that leads to bone marrow regeneration failure.

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Written by Peng Miao Yun
Internal Medicine
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The main diagnostic basis for aplastic anemia

Aplastic anemia is caused by a variety of reasons leading to bone marrow hematopoietic failure. So, what is the main diagnostic basis for diagnosing aplastic anemia? It is primarily the bone marrow examination, which shows decreased or severely decreased proliferation at least in one site, such as active proliferation, significant reduction in megakaryocytes, and an increase in non-hematopoietic cells in the bone marrow's granular components. Additionally, there can be a decrease in total blood cells, white cells, red cells, etc., and a reduction in the absolute value of reticulocytes.

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Written by Zhang Xiao Le
Hematology
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The differences between aplastic anemia and megaloblastic anemia.

Aplastic anemia is a type of bone marrow failure syndrome where patients can present with reduced total blood cells in the peripheral blood, without enlargement of the liver, spleen, or lymph nodes, and an increased ratio of peripheral blood lymphocytes. Bone marrow indicates low regeneration, reduced hematopoietic tissue, and increased non-hematopoietic tissue, with the condition arising from changes in the bone marrow microenvironment leading to a reduction in blood cells. Megaloblastic anemia, also known as nutritional anemia, is primarily caused by a lack of folate and vitamin B12, leading to a red blood cell synthesis disorder and resulting in anemia. Severe megaloblastic anemia can also present with reduced total blood cells. However, the red blood cells typically exhibit macrocytic anemia. In contrast, aplastic anemia generally presents with normocytic anemia.